有机磷阻燃剂的毒性及其作用机制研究进展  

Progress in the study of toxicity mechanisms of organophosphorus flame retardants

作　　者：周圆鸳 廖晗钰 毛张琦 张剑云[1] ZHOU Yuanyuan;LIAO Hanyu;MAO Zhangqi;ZHANG Jianyun(School of Public Health,Hangzhou Normal University,Zhejiang 311121,China)

机构地区：[1]杭州师范大学公共卫生学院,浙江311121

出　　处：《工业卫生与职业病》2023年第6期560-564,共5页Industrial Health and Occupational Diseases

基　　金：浙江省自然科学基金项目(LQ20B070006);浙江省教育厅一般科研项目(高校专业学位研究生培养模式改革专项)(Y202147713)。

摘　　要：随着溴系阻燃剂的逐步禁用,有机磷酸酯类阻燃剂被广泛应用。近年来随着研究的不断深入,有机磷酸酯阻燃剂(organophosphate flame retardants,OPFRs)带来的环境影响以及对人群健康效应已广受关注,既往研究证实OPFRs具有多种毒性效应,主要表现为神经毒性、内分泌干扰效应、脏器毒性、生殖和发育毒性等。进行OPFRs对生物体神经毒性、内分泌干扰效应、脏器毒性、生殖与发育毒性及相关毒作用机制综述,旨在对OPFRs暴露人群的健康影响提供参考和科学依据。With the gradual banning of brominated flame retardants,the usage of organophosphate flame retar⁃dants(OPFRs)has increased rapidly.In recent years,the environmental impact and health effects of OPFRs on human beings have been widely concerned with the continuous research.This paper reviews the neurotoxicity,endocrine disrupting effects,organ toxicity,reproductive and developmental toxicity and related toxicity mechanisms of OPFRs,with the aim of providing a reference and scientific basis for more accurate and comprehensive assessment of the health risks of OPFRs exposure.

关 键 词：有机磷阻燃剂 生物毒性 毒性机制 

分 类 号：R994.6[医药卫生—毒理学]