子痫前期患者胎盘微循环状态与妊娠结局的相关性  

Correlation between placental microcirculation status and pregnancy outcomes in patients with preeclampsia

作　　者：何红[1] 张强[2] 李晖[1] 焦顺 HE Hong;ZHANG Qiang;LI Hui;JIAO Shun(Department of Obstetrics,Jingzhou Hospital Affiliated to Yangtze University(Jingzhou Central Hospital),Jingzhou Hubei 434020,China;Department of Ultrasound,Jingzhou Hospital Affiliated to Yangtze University(Jingzhou Central Hospital),Jingzhou Hubei 434020,China)

机构地区：[1]长江大学附属荆州医院(荆州市中心医院)产科,湖北荆州434020 [2]长江大学附属荆州医院(荆州市中心医院)超声科,湖北荆州434020

出　　处：《中国妇产科临床杂志》2024年第1期67-70,共4页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：荆州市医疗卫生科技计划项目(201735)。

摘　　要：目的 探讨子痫前期患者胎盘微循环状态与妊娠结局的相关性。方法 选取2020年8月至2022年8月荆州市中心医院收治的子痫前期患者62例作为观察组,纳入同期孕周相同的健康体检孕妇62例作为对照组,比较两组胎盘微循环参数的差异,将观察组患者按妊娠结局分为良好妊娠结局43例和不良妊娠结局组19例,分析胎盘微循环参数与子痫前期患者妊娠结局的相关性。结果 观察组BMI、入院收缩压、舒张压、ALT、AST、LDH、BUN、Cr、UA以及家族高血压史率、搏动指数和阻力指数、早产、胎儿窘迫发生率均高于对照组(P <0.05),观察组单位面积血管数、TAV低于对照组(P <0.05);不良妊娠结局组单位面积血管数、S/D、TAV低于良好妊娠结局组(P <0.05),搏动指数和阻力指数高于良好妊娠结局组(P <0.05);ROC分析结果显示,胎盘中央单位面积血管数、S/D、TAV、搏动指数、阻力指数对子痫前期患者不良妊娠结局的曲线下面积均高于0.75。Logistic分析结果显示,单位面积血管数<0.12/cm2、S/D<2.28、TAV<10.73 cm/s、搏动指数>0.77、阻力指数>0.74均为子痫前期不良妊娠结局的危险因素(P <0.05)。结论 子痫前期孕妇胎盘微循环参数与不良妊娠结局相关,可作为临床参考。Objective To explore the correlation between placental microcirculation status and pregnancy outcomes in patients with preeclampsia.Methods 62 patients with preeclampsia who were treated in Jingzhou Central Hospital from August 2020 to August 2022 were selected as observation group,and 62 healthy pregnant women of the same gestational week who underwent physical examination were included in control group.The differences in placental microcirculation parameters were compared.According to the pregnancy outcomes,the patients in observation group were divided into good pregnancy outcomes group(43 cases) and poor pregnancy outcomes group(19 cases).The correlation between placental microcirculation parameters and pregnancy outcomes in patients with preeclampsia was analyzed.Results The BMI,systolic blood pressure and diastolic blood pressure at admission,ALT,AST,LDH,BUN,Cr,UA and family history of hypertension,pulsatility index,resistance index and incidence rates of premature delivery and fetal distress in observation group were higher than those in control group(P < 0.05),while the number of blood vessels per unit area and TAV were lower than those in control group(P < 0.05).The number of blood vessels per unit area,S/D and TAV were lower in poor pregnancy outcome group than those in good pregnancy outcome group(P < 0.05),while the pulsatility index and resistance index were higher than those in good pregnancy outcome group(P < 0.05).ROC analysis results showed that the areas under the curves of the number of blood vessels per unit area of placenta,S/D,TAV,pulsatility index and resistance index on predicting the poor pregnancy outcomes in patients with preeclampsia were higher than 0.75.Logistic analysis showed that the number of blood vessels per unit area < 0.12/cm2,S/D < 2.28,TAV < 10.73 cm/s,pulsatility index > 0.77 and resistance index > 0.74 were all risk factors for poor pregnancy outcomes of preeclampsia(P < 0.05).Conclusion The parameters of placental microcirculation in pregnant women with preeclampsia are

关 键 词：子痫前期 胎盘微循环 妊娠结局 相关性分析 

分 类 号：R714.244[医药卫生—妇产科学]