Janus激酶-信号转导及转录激活因子信号通路抑制剂在白癜风治疗中的新进展  

JAK-STAT inhibitors in the treatment of vitiligo

作　　者：古丽孜巴·图尔荪 屈园园[2] Guliziba·Tuersun;Qu Yuanyuan(Graduate School of Xinjiang Medical University,Urumqi 830001,China;Department of Dermatology and Venereology,People′s Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Clinical Research Center for Dermatologic Diseases,Xinjiang Key Laboratory of Dermatology Research(XJYS1707),Urumqi 830001,China)

机构地区：[1]新疆医科大学研究生院,乌鲁木齐830001 [2]新疆维吾尔自治区人民医院皮肤性病科,新疆皮肤病临床医学研究中心,新疆皮肤病研究重点实验室(XJYS1707),乌鲁木齐830001

出　　处：《中华皮肤科杂志》2024年第1期71-75,共5页Chinese Journal of Dermatology

基　　金：中国研究型医院学会科研课题 (Y2021FH-PFK06)。

摘　　要：近年来,随着对白癜风发病机制的深入研究,Janus激酶(JAK)-信号转导及转录激活因子(STAT)信号通路越来越受到关注.本文综述了JAK-STAT信号通路在白癜风发生过程中的作用,并回顾了目前正在研究或已用于治疗白癜风的JAK-STAT抑制剂.In recent years,with the in-depth research on the pathogenesis of vitiligo,the Janus kinase(JAK)-signal transducer and activator of transcription(STAT)pathway has attracted more and more attention.This review summarizes the role of the JAK-STAT signaling pathway in the development of vitiligo,as well as JAK-STAT inhibitors that are currently being studied or have been used in the treatment of vitiligo.

关 键 词：白癜风 Janus激酶类 STAT转录因子类 JAK-STAT抑制剂 治疗 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]