神经源性炎症因子在白癜风发病机制中的研究进展  

Role of neurogenic inflammatory factors in the pathogenesis of vitiligo

作　　者：王浩洋 王怡丹 鲁严 Wang Haoyang;Wang Yidan;Lu Yan(Department of Dermatology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]南京医科大学第一附属医院皮肤科,南京210000

出　　处：《中华皮肤科杂志》2024年第1期78-81,共4页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81872541)。

摘　　要：白癜风作为一种获得性色素脱失性疾病,神经因素可能在其发病机制中起着重要作用,支配皮肤的感觉神经释放的神经源性炎症因子可以直接或间接调节角质形成细胞、黑色素细胞、朗格汉斯细胞、真皮树突细胞、肥大细胞、真皮微血管内皮细胞和免疫细胞的功能.本文综述与白癜风发生发展密切相关的几种神经源性炎症因子的作用,包括神经肽Y、降钙素基因相关肽、儿茶酚胺和神经生长因子等,以期为临床上治疗白癜风提供新的思路.Vitiligo is an acquired depigmented disease,and neurological factors may play an important role in its pathogenesis.Neurogenic inflammatory factors released by sensory nerves that control the skin can directly or indirectly regulate functions of keratinocytes,melanocytes,Langerhans cells,dermal dendritic cells,mast cells,dermal microvascular endothelial cells and immune cells.This review summarizes roles of several relevant neurogenic inflammatory factors in the occurrence and development of vitiligo,including neuropeptide Y,calcitonin gene-related peptide,catecholamines and nerve growth factor,with a view to providing new ideas for clinical treatment of vitiligo.

关 键 词：白癜风 神经分泌系统 自身免疫 神经和精神因素 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]