血清IL-17、sCD14、NLR在COPD合并肺部感染患者中的表达及预后相关分析  

Expression and prognosis correlation analysis of serum IL-17,sCD14 and NLR in patients with COPD and pulmonary infection

作　　者：时海爽 赵浩杰 SHI Hai-shuang;ZHAO Hao-jie(Second Ward of Infection Department,Henan Provincial People's Hospital,Zhengzhou 450000,China;Hematooncology Department,Henan Hospital of Integrated Traditional Chinese and Western Medicine,Zhengzhou 450000,China)

机构地区：[1]河南省人民医院感染科二病区,郑州450000 [2]河南省中西医结合医院血液肿瘤科,郑州450000

出　　处：《医药论坛杂志》2023年第21期72-75,81,共5页Journal of Medical Forum

摘　　要：目的分析血清白细胞介素-17(interleukin-17,IL-17)、可溶性白细胞分化抗原14(soluble leukocyte differentiation antigen 14,sCD14)、中性粒细胞/淋巴细胞比值(neutrophil/lymphocyte ratio,NLR)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并肺部感染患者中的表达及预后相关性。方法选取2022年1月—2022年12月河南省人民医院COPD患者152例,按照是否合并肺部感染分为感染组(n=84例)和非感染组(n=68),并选取同期健康体检者84例作为对照组。均检测3组血清IL-17、sCD14、NLR水平,比较3组检测结果,分析不同感染程度患者的血清IL-17、sCD14、NLR水平。按照预后情况将COPD合并肺部感染患者分为死亡组(n=11)和存活组(n=73),比较死亡组和存活组血清IL-17、sCD14、NLR水平,Pearson分析血清IL-17、sCD14、NLR水平与COPD合并肺部感染患者预后的相关性。结果感染组血清IL-17、sCD14、NLR水平较非感染组和对照组高,非感染组血清IL-17、sCD14、NLR水平较对照组高(P<0.05);重度感染患者血清IL-17、sCD14、NLR水平较轻度感染和中度感染患者高,中度感染患者血清IL-17、sCD14、NLR水平较轻度感染患者高(P<0.05);死亡组血清IL-17、sCD14、NLR水平较存活组高(P<0.05);Pearson分析结果显示,血清IL-17(r=541)、sCD14(r=473)、NLR(r=619)水平与COPD合并肺部感染患者住院期间死亡呈正相关(P<0.05)。结论血清IL-17、sCD14、NLR水平在COPD合并肺部感染患者中显著升高,且感染程度越重IL-17、sCD14、NLR水平越高,三种指标联合检测能良好预测COPD合并肺部感染患者的预后情况。Objective To analyze the expression and prognosis correlation analysis of serum interleukin-17(IL-17),soluble leukocyte differentiation antigen 14(sCD14)and neutrophil/lymphocyte ratio(NLR)in patients with chronic obstructive pulmonary disease(COPD)and pulmonary infection.Methods A total of 152 patients with COPD in our hospital from January 2022 to December 2022 were enrolled,and they were divided into infection group(n=84 cases)and non-infection group(n=68)according to whether pulmonary infection was present,and 84 healthy patients were selected as the control group.The serum IL-17,sCD14 and NLR levels of the three groups were measured,and the serum IL-17,sCD14 and NLR levels of patients with different levels of infection were analyzed.According to the prognosis,patients with COPD and pulmonary infection were divided into death group(n=11)and survival group(n=73),and the serum IL-17,sCD14 and NLR levels of the death group and the survival group were compared.The correlation between serum levels of IL-17,sCD14 and NLR and prognosis of patients with COPD combined with pulmonary infection was analyzed by Pearson.Results The serum levels of IL-17,sCD14 and NLR in the infected group were higher than those in the non-infected group and the control group,and the serum levels of IL-17,sCD14 and NLR in the non-infected group were higher than those in the control group(P<0.05).The serum levels of IL-17,sCD14 and NLR in the severely infected patients were higher than those in the mildly infected and moderately infected patients,the serum IL-17,sCD14 and NLR levels in the moderately infected patients were higher than those in the mildly infected patients(P<0.05).The serum levels of IL-17,sCD14 and NLR in the death group were higher than those in the mildly infected patients(P<0.05).The serum levels of IL-17,sCD14 and NLR in the death group were higher than those in the survival group(P<0.05).Pearson analysis showed that serum levels of IL-17(r=541),sCD14(r=473),and NLR(r=619)were positively correlated with mortality during

关 键 词：慢性阻塞性肺疾病 肺部感染 白细胞介素-17 可溶性白细胞分化抗原14 中性粒细胞/淋巴细胞比值 

分 类 号：R563[医药卫生—呼吸系统]