针刺联合化痰助孕方对多囊卵巢综合征患者(痰湿困阻型)IL-6、HOMA-IR、HS-CRP、性激素及妊娠结局的影响  

Effects of acupuncture combined with Huatan and Progesterone prescription on IL-6,HOMA-IR,HS-CRP,sex hormone and pregnancy outcome in patients with polycystic ovary syndrome(phlegm-dampness and difficulty)

作　　者：邓晓丰 徐琳 DENG Xiaofeng;XU Lin(The Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing100029,China;Department of Gynecology,Guang'anmen Hospital,Beijing 100053,China)

机构地区：[1]北京中医药大学第三附属医院,北京100029 [2]广安门医院妇科,北京100053

出　　处：《中国免疫学杂志》2024年第1期163-167,共5页Chinese Journal of Immunology

摘　　要：目的:探讨针刺联合化痰助孕方对多囊卵巢综合征(痰湿困阻型)患者的影响。方法:128例多囊卵巢综合征(痰湿困阻型)患者均于2017年9月至2021年3月于北京中医药大学第三附属医院就诊,并随机分为对照组和观察组,每组64例。对照组采用西医常规治疗,观察组联合针刺及化痰助孕方治疗,治疗3个月经周期后比较疗效。结果:治疗后观察组血清TGF-β1、IL-6、超敏C反应蛋白(HS-CRP)水平低于对照组(P<0.05),观察组胰岛素抵抗指数(HOMA-IR)、子宫内膜厚度、卵巢体积低于对照组(P<0.05),观察组血清雌激素(E2)水平高于对照组,促黄体生成素(LH)、促卵泡激素(FSH)水平低于对照组(P<0.05);治疗后观察组排卵率(79.69%)、妊娠率(57.81%)均高于对照组,两组流产率差异无统计学意义(P>0.05);观察组不良反应总发生率(7.81%)低于对照组(21.88%),差异有统计学意义(P<0.05)。结论:对于多囊卵巢综合征(痰湿困阻型)患者而言,联合针刺及化痰助孕方效果显著,有助于减轻炎症反应,减轻胰岛素抵抗,促进排卵及妊娠,提高临床疗效。Objective:To explore the effect of acupuncture combined with Huatan and Progesterone prescription on patients with polycystic ovary syndrome(phlegm-dampness and difficulty).Methods:Total 128 patients with polycystic ovary syndrome(phlegm-dampness and difficulty)were treated in the Third Affiliated Hospital of Beijing University of Chinese Medicine from Septem-ber 2017 to March 2021,and randomly divided into control group and observation group,with 64 patients in each group.Control group received conventional treatment in Western medicine,and observation group was treated with acupuncture and the Huatan and Progesterone prescription.After 3 menstrual cycles,the efficacy was compared.Results:After treatment,serum TGF-β1,IL-6 and high-sensitivity C-reactive protein(HS-CRP)levels of observation group were lower than that of control group(P<0.05),insulin resis-tance index(HOMA-IR),endometrial thickness and ovarian volume in observation group were lower than those in control group(P<0.05),serum estrogens(E2)level in observation group was higher than that in control group,while levels of luteinizing hormone(LH)and follicle-stimulating hormone(FSH)were lower than that in control group(P<0.05).After treatment,ovulation rate(79.69%)and pregnancy rate(57.81%)in observation group were higher than those in control group,and there was no significant difference in abor-tion rate between the two groups(P>0.05).Total incidence of adverse reactions in observation group(7.81%)was lower than that in control group(21.88%),and the difference was statistically significant(P<0.05).Conclusion:For patients with polycystic ovary syn-drome(phlegm-dampness and difficulty),combined acupuncture and Huatan and Progesterone prescription has significant effect,which can help to reduce inflammatory reaction,reduce insulin resistance,promote ovulation and pregnancy,and improve clinical efficacy.

关 键 词：针刺 化痰助孕方 多囊卵巢综合征 痰湿困阻型 IL-6 HOMA-IR 性激素 妊娠结局 

分 类 号：R71[医药卫生—妇产科学]