土壤多环芳烃生物可给性测定的体外胃肠模拟法研究进展  

Advances of in vitro Gastrointestinal Simulation Methods for Determining Bioaccessibility of Polycyclic Aromatic Hydrocarbons(PAHs)in Soil

作　　者：马俊超 高彦征[1] 秦超 MA Junchao;GAO Yanzheng;QIN Chao(Institute of Organic Contaminant Control and Soil Remediation,Nanjing Agricultural University,Nanjing 210095,China)

机构地区：[1]南京农业大学土壤有机污染控制与修复研究所,南京210095

出　　处：《土壤》2023年第6期1161-1169,共9页Soils

基　　金：国家自然科学基金项目(42107221);国家杰出青年科学基金项目(41925029)资助。

摘　　要：经口摄入是土壤多环芳烃(PAHs)人体暴露的重要途径,有效评估土壤中PAHs的生物可给性是全面评估土壤PAHs人体健康风险的重要组成部分。然而,测定土壤PAHs生物可给性的体外胃肠模拟方法众多,至今国内外尚缺乏统一标准。由于不同体外模拟方法测定的结果差异较大,制约了土壤PAHs人体健康风险评估的发展。基于此,本文综述了PAHs生物可给性测定所用的多种体外胃肠模拟方法及进展,并针对PAHs生物可给性测定方法存在的问题,建议未来构建土壤PAHs生物可给性测定标准方法的相关研究应从生理条件、吸附材料的选择、体内模型的验证这3方面综合考虑。Oral ingestion is an important route of human exposed to soil polycyclic aromatic hydrocarbons(PAHs).Effective assessment of the bioaccessibility of PAHs is an important component of a comprehensive assessment of the human health risk of PAHs in soil.However,there are many in vitro gastrointestinal simulation methods to evaluate the bioaccessibility of soil PAHs,and there is still no uniform standard in China as well as abroad.The development of human health risk assessment of soil PAHs has been hampered by the large variation in the results of different in vitro simulation methods.Thus,this paper reviewed various in vitro gastrointestinal simulation methods and the related advances for PAHs bioavailability determination,and suggested that future research on the construction of standard methods for PAHs bioaccessibility determination in soils should be based on three aspects:physiological conditions,selection of adsorbent materials,and validation of in vivo models.

关 键 词：有机污染物 PAHS 体外胃肠模拟 生物有效性 人体健康风险评估 

分 类 号：X-1[环境科学与工程]