顺-3-己烯酸甲酯还原制备叶醇的工艺研究  

Preparation of Leaf Alcohol by Reduction of Methyl-cis-3-hexenoate

作　　者：吴兵 王选智 Wu Bing;Wang Xuanzhi(Shandong Huaxin Flavor Co.,Ltd.,Shandong,274000)

机构地区：[1]山东华馨香料有限公司,山东274000

出　　处：《当代化工研究》2024年第3期150-153,共4页Modern Chemical Research

摘　　要：以顺-3-己烯酸甲酯为原料,探究不同反应体系对叶醇合成收率的影响。并优化了以顺-3-己烯酸甲酯、乙醇、氯化钙为原料的还原体系工艺条件,得到的最优反应条件为:顺-3-己烯酸甲酯用量为38.4g,m(95%乙醇):m(顺-3-己烯酸甲酯)=6;n(CaCl_(2)):n(顺-3-己烯酸甲酯)=0.8;n(NaBH_(4)):n(顺-3-己烯酸甲酯)=1.2,反应温度20℃,反应1h,叶醇收率为80.92%,并在此基础上扩大到公斤级反应,最终得到叶醇收率为80%以上,具有广阔的工业化应用前景。The effects of different reaction systems on the synthesis yield of leaf alcohol were studied with methyl-cis-3-hexenoate as raw material.The process conditions of the reduction system under methyl-cis-3-hexenoate,ethanol and calcium chloride as raw materials were optimized.The optimal process conditions were determined as follows:the amount of methyl-cis-3-hexenoate was 38.4 g,m(95%ethanol):m(methyl-cis-3-hexenoate)was 6;n(CaCl_(2)):n(methyl-cis-3-hexenoate)was 0.8;n(NaBH_(4)):n(methyl-cis-3-hexenoate)was 1.2,reaction temperature was 20℃,reaction time was 1 h,the yield of leaf alcohol is 80.92%,and on this basis to expand to kilogram reaction,the final yield of leaf alcohol is higher than 80%.

关 键 词：顺-3-己烯酸甲酯 叶醇 还原 硼氢化钠 

分 类 号：TQ[化学工程]