创伤性骨折后患者ALP、PDGF、NGF及微量元素水平对患者骨折愈合的影响  

Effect of ALP,PDGF,NGF and Trace Elements Levels on Fracture Healing in Patients with Traumatic Fracture

作　　者：梁雁冰[1] 欧阳晟[1] 孙秀钦[1] 叶向阳[2] LIANG Yanbing;OUYANG Sheng;SUN Xiuqin;YE Xiangyang(Orthopedic Third Department,Nanyang Central Hospital,Nanyang 473000,China;Orthopedic First Department,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院骨三科,河南南阳473000 [2]南阳市中心医院骨一科,河南南阳473000

出　　处：《河南医学研究》2023年第24期4514-4517,共4页Henan Medical Research

基　　金：河南省重点研发与推广专项(182102310466)。

摘　　要：目的探究碱性磷酸酶(ALP)、血小板衍生生长因子(PDGF)、神经生长因子(NGF)及微量元素对创伤性骨折愈合的影响。方法前瞻性选取南阳市中心医院2022年12月至2023年3月收治的70例骨折愈合患者为研究对象(愈合组),另选取同期复查结果为延迟愈合的70例患者为延迟愈合组。比较两组血清ALP、PDGF、NGF和微量元素水平。结果愈合组血清ALP、PDGF、NGF水平及微量元素Fe、Zn、Se水平高于延迟愈合组,Cu水平低于延迟愈合组(P<0.05)。logistic回归分析显示,PDGF、Cu均为骨折愈合延迟的影响因素(OR=0.990、4.837,P<0.05)。结论PDGF、Cu水平是创伤性骨折后患者延迟愈合的影响因素,可为相关临床诊疗提供依据。Objective To study the effect of alkaline phosphatase(ALP),platelet derived growth factor(PDGF),nerve growth factor(NGF)and microelements in patients with traumatic fracture.Methods From December 2022 to March 2023,70 patients with traumatic fracture of Nanyang Central Hospital were selected as subjects(healing group).Additionally,70 patients with delayed healing were selected as the delayed healing group based on their follow-up results during the same period.The levels of serum ALP,PDGF,NGF and trace elements were compared between the two groups.Results The serum levels of ALP,PDGF,NGF and trace elements Fe,Zn and Se in the healing group were higher than those in the delayed healing group,and the level of Cu was lower than that in the delayed healing group(P<0.05).Logistic regression model showed that,PDGF and Cu were influential factors for delayed fracture healing(OR=0.990,4.837,P<0.05).Conclusion The levels of PDGF and Cu are influencing factors for delayed healing of fractures,which can provide evidence for relevant clinical diagnosis and treatment.

关 键 词：碱性磷酸酶 血小板衍生生长因子 神经生长因子 微量元素 

分 类 号：R683[医药卫生—骨科学]