HPV16/18不同感染模式与宫颈病变的相关性  

Correlation Between Different Modes of HPV16/18 Infection and Cervical Lesions

作　　者：张艳 王悦 吴丹婷 朱康宁 ZHANG Yan;WANG Yue;WU Danting;ZHU Kangning(Department of Gynecology,Henan Provincial People’s Hospital/Zhengzhou University People’s Hospital,Zhengzhou 450003,China;Department of Pathology,Henan Provincial People’s Hospital/Zhengzhou University People’s Hospital,Zhengzhou 450003,China;Department of Clinical Laboratory,Henan Provincial People’s Hospital/Zhengzhou University People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院/郑州大学人民医院妇科,河南郑州450003 [2]河南省人民医院/郑州大学人民医院病理科,河南郑州450003 [3]河南省人民医院/郑州大学人民医院检验科,河南郑州450003

出　　处：《河南医学研究》2023年第24期4525-4528,共4页Henan Medical Research

摘　　要：目的本研究旨在探讨人乳头瘤病毒(HPV)16/18型感染的不同模式(单一感染或混合感染)与宫颈病变的相关性。方法统计2019年1月1日至2021年12月31日河南省人民医院筛查出HPV16/18型感染且行阴道镜活检的患者,回顾性分析HPV16/18单一感染及HPV16/18合并其他高危型人乳头瘤病毒(HrHPV)感染患者的宫颈病变程度(宫颈低级别鳞状上皮内病变/宫颈高级别上皮内病变/宫颈浸润癌)。结果感染模式分布:所有HPV16/18型感染(共5992例)中,单一HPV16感染占比最高(42.09%),HPV16和其他HrHPV混合感染次之(34.41%);单一HPV18感染占9.88%。致病程度:宫颈高级别上皮内病变(高级别鳞状上皮内病变/原位腺癌)比率方面,单一HPV16最高(15.74%),高于HPV16合并其他HrHPV(8.78%)和单一HPV18(6.92%),差异有统计学意义(P<0.05);HPV16/18混合感染(7.41%)高于单一HPV18感染(6.92%),但差异无统计学意义(P>0.05)。结论HPV16/18型感染中最多见的感染模式是单一HPV16感染。HPV16/18不同感染模式致病风险不同,单一HPV16感染对宫颈病变致病力最强。Objective To explore the different effects of different modes of human papillomavirus(HPV)16/18 infection(mono-infection or mixed infection)on the degree of cervical lesions.Methods Patients with HPV16/18 infection who underwent colposcopic biopsy in Henan Provincial People’s Hospital from January 1,2019 to December 31,2021 were counted.The degree of cervical lesions(low-grade squamous intraepithelial cervical lesion/high-grade intraepithelial cervical lesion/cervical invasive carcinoma)in patients with HPV16/18 mono-infection and HPV16/18 combined with other high-risk human papillomavirus(HrHPV)infection were retrospectively analyzed.Results Distribution of infection pattern:among all HPV16/18 infected cases(5992 cases),the highest percentage of single HPV16 infection(42.09%)was followed by mixed HPV16 and other HrHPV infections(34.41%),and the prevalence of single HPV18 infection was 9.88%.Degree of pathogenicity:in terms of the proportion of cervical≥high-grade intraepithelial lesions(HSIL/AIS),the highest proportion of single HPV16 infection(15.74%)was higher than the mixed infection of HPV16 and other HrHPV(8.78%)and single HPV18(6.92%),with significant differences(P<0.05).The proportion of HPV16/18 mixed infection(7.41%)was higher than single HPV18 infection(6.92%),but the difference was not statistically significant(P>0.05).Conclusion The most common mode of HPV16/18 infection was single HPV16 infection.Different HPV16/18 infection patterns have different pathogenic risks.Single HPV16 infection was the most pathogenic.

关 键 词：人乳头瘤病毒16/18型 感染模式 宫颈病变 

分 类 号：R711.74[医药卫生—妇产科学]