中医火针联合温阳散结汤治疗湿热风毒型结节性痒疹临床疗效研究  

Clinical efficacy of fire needle combined with the Wenyang Sanjie decoction on damp-heat-wind-toxin type prurigo nodularis

作　　者：邹文娟 向丽萍[1] ZOU Wenjuan

机构地区：[1]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《中医临床研究》2023年第34期111-116,共6页Clinical Journal Of Chinese Medicine

基　　金：湖南中医药大学校级基金项目(2021XJJJ059)。

摘　　要：目的:观察中医火针联合温阳散结汤治疗湿热风毒型结节性痒疹的临床疗效。方法:选取2020年1月-2022年1月湖南中医药大学第二附属医院收治的90例结节性痒疹患者,按照随机数字表法将其分为观察组和对照组,每组各45例。两组均给予常规西医疗法,对照组加用火针治疗;观察组在对照组基础上加用温阳散结汤治疗,均治疗1个月。比较治疗后两组间临床疗效;比较治疗前后两组患者间临床症状、体征评分、瘙痒程度视觉模拟评分法(Visual Analogue Scale,VAS)评分及皮损严重程度评分,血清生化指标[肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、P物质(Serum Substance P,SP)、免疫球蛋白E(Immunoglobulin E,IgE)及单胺氧化酶(Monoamine Oxidase,MAO)]表达水平变化,统计治疗期间不良反应情况。结果:观察组总有效率显著高于对照组(P <0.05)。治疗前,两组皮损数目及大小、瘙痒程度、角化程度评分差异无统计学意义(P>0.05);治疗后,两组临床症状、体征评分均较治疗前明显降低(P <0.05),且观察组治疗后评分显著低于对照组(P <0.05)。治疗前,两组患者瘙痒程度VAS评分及皮损严重程度评分差异无统计学意义(P> 0.05);治疗后,两组评分均较治疗前明显降低(P <0.05),且观察组治疗后评分显著低于对照组(P <0.05)。治疗前,两组患者血清TNF-α、SP、IgE、MAO水平差异无统计学意义(P> 0.05);治疗后,两组患者血清TNF-α、SP、IgE、MAO水平均较治疗前明显降低(P <0.05),且观察组治疗后显著低于对照组(P <0.05)。两组患者治疗期间不良反应发生率的差异无统计学意义(P> 0.05)。结论:温阳散结汤联合火针治疗结节性痒疹疗效更佳,能有效缓解患者瘙痒及皮损症状,减轻炎症反应。Objective:To observe the clinical efficacy of fire needle combined with the Wenyang Sanjie decoction(温阳散结汤)on prurigo nodularis of damp-heat-wind-toxin type.Methods:A total of 90 patients with prurigo nodularis treated in the Second Affiliated Hospital of Hunan University of traditional Chinese medicine from January 2020 to January 2022 were randomly divided into the observation group and the control group,45 cases in each group.Both groups were treated with conventional western medicine,while the control group was treated by fire needle,the observation group was treated with the Wenyang Sanjie decoction more,for 1 month.The clinical efficacy was compared between the two groups after treatment.The clinical symptoms,signs,pruritus score VAS,adverse reactions and other indicators were compared between the two groups before and after treatment.Results:After treatment,the total effective rate in the observation group was significantly higher than the control group(P<0.05).Before treatment,there was no significant difference in the number and size of skin lesions,pruritus and keratosis scores between the two groups(P>0.05).After treatment,the scores of clinical symptoms and signs in the two groups were significantly lower than those before treatment(P<0.05),and the scores in the observation group after treatment were significantly lower than those in the control group(P<0.05).Before treatment,there was no significant difference in the VAS score of pruritus and the severity score of skin lesions between the two groups(P>0.05).After treatment,the scores in the two groups were significantly lower than those before treatment(P<0.05),and the scores in the observation group after treatment were significantly lower than those in the control group(P<0.05).Before treatment,There was no significant difference in the levels of serum TNF-α,SP,IgE and MAO(P>0.05).After treatment,the TNF-α,SP,IgE and MAO in the observation group were significantly lower than those in the control group after treatment(P<0.05).There was n

关 键 词：温阳散结汤 火针 结节性痒疹 临床研究 

分 类 号：R275[医药卫生—中医皮科]