中药抑制卵巢癌血管生成的作用机制研究进展  

Advances in mechanism of traditional Chinese medicine in inhibiting angiogenesis in ovarian cancer

作　　者：唐茂艳 丁丹妮 解娅娅 申芳 李佳 刘芳媛 韩凤娟[2] TANG Mao-yan;DING Dan-ni;XIE Ya-ya;SHEN Fang;LI Jia;LIU Fang-yuan;HAN Feng-juan(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学第一附属医院,黑龙江哈尔滨150040

出　　处：《中国中药杂志》2023年第24期6572-6581,共10页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82274566,82074484)。

摘　　要：卵巢癌是妇科三大癌症之一。卵巢癌早期症状隐匿,发现时多已进展至晚期,手术治疗联合化疗是目前的主要治疗手段,但5年生存率仍低于45%。血管生成是卵巢癌生长和转移的关键步骤。抑制卵巢癌血管生成已经成为抗肿瘤靶向治疗的新热点,具有不易耐药、特异性高、副作用小、抗瘤谱广等诸多优点。现代研究证实,中药可通过抑制促血管生长因子的表达、上调抗血管生成因子的表达、抑制血管内皮细胞增殖及降低肿瘤微血管的密度、调节相关信号通路等作用机制抑制肿瘤血管新生,在卵巢癌的治疗方面具有独特优势。该文基于中药抑制卵巢癌血管生成以发挥抗卵巢癌作用方面做一综述,以期为临床卵巢癌治疗策略的优化提供借鉴与参考。Ovarian cancer is one of the three major cancers in gynecology.Ovarian cancer has insidious symptoms in its early stages and mostly has progressed to advanced stages when detected.Surgical treatment combined with chemotherapy is currently the main treatment,but the 5-year survival rate is still less than 45%.Angiogenesis is a key step in the growth and metastasis of ovarian cancer.The inhibition of ovarian cancer angiogenesis has become a new hotspot in anti-tumor targeted therapy,which has many advantages such as less drug resistance,high specificity,few side effects,and broad anti-tumor spectrum.Modern research has confirmed that traditional Chinese medicine(TCM)can inhibit tumor angiogenesis by inhibiting the expression of pro-angiogenic factors,up-regulating the expression of anti-angiogenic factors,inhibiting the proliferation of vascular endothelial cells,reducing the density of tumor microvessels,and regulating related signaling pathways,with unique advantages in the treatment of ovarian cancer.This paper presented a review of the role of TCM in inhibiting ovarian cancer angiogenesis in order to provide references for the optimization of clinical ovarian cancer treatment strategies.

关 键 词：卵巢癌 血管生成 VEGF 中药 作用机制 

分 类 号：R273[医药卫生—中西医结合]