Prevalence and factors associated with pentavalent vaccination:a cross-sectional study in Southern China  

作　　者：Jianing Xu Yujie Cui Chuican Huang Yuanyuan Dong Yunting Zhang Lichun Fan Guohong Li Fan Jiang 

机构地区：[1]School of Public Health,Shanghai Jiao Tong University School of Medicine,227 South Chong Qing Road,Shanghai 200025,China [2]China Hospital Development Institute,Shanghai Jiao Tong University,Shanghai,China [3]Department of Child Health Care,Hainan Women and Children’s Medical Center,Haikou,China [4]Child Health Advocacy Institute,National Children’s Medical Center,Shanghai Children’s Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai,China [5]Department of Developmental and Behavioral Pediatrics,National Children’s Medical Center,Shanghai Children’s Medical Center,School of Medicine,Shanghai Jiao Tong University,227 South Chong Qing Road,Shanghai 200025,China [6]Pediatric Translational Medicine Institute,National Children’s Medical Center,Shanghai Children’s Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai,China [7]Shanghai Center for Brain Science and Brain-Inspired Technology,Shanghai,China

出　　处：《Infectious Diseases of Poverty》2023年第5期32-44,共13页贫困所致传染病（英文）

基　　金：This work was supported by the Bill&Melinda Gates Foundation(Grant No.INV-049539);the Key Research and Development Program of Hainan Province(Grant No.ZDYF2020210);the Project of the National Social Science Fund of China(Grant No.20BGL264);the Shanghai Public Health System Construction Three-Year Action Plan(Grant No.GWVI-11.1-48)。

摘　　要：Background Immunization is one of the most far-reaching and cost-effective strategies for promoting good health and saving lives.A complex immunization schedule,however,may be burdensome to parents and lead to reduced vaccine compliance and completion.Thus,it is critical to develop combination vaccines to reduce the number of injections and simplify the immunization schedule.This study aimed to investigate the current status of the pentavalent diphtheria-tetanus-acellular pertussis inactivated poliomyelitis andHaemophilus influenzae type B conjugate(DTaP-IPV/Hib)vaccination in Southern China as well as explore the factors in the general population associated with uptake and the differences between urban and rural populations.Methods A cross-sectional study was conducted with recently enrolled kindergarten students in Hainan Province between December 2022 and January 2023.The study employed a stratified multistage cluster random sampling method.Information regarding the demographic characteristics and factors that influence decisions were collected from the caregivers of children via an online questionnaire.Multivariate logistic regression was used to determine the factors associated with the status of DTap-IPV/Hib vaccinations.Results Of the 4818 valid responses,95.3%of children were aged 3-4 years,and 2856(59.3%)held ruralhukou.Coverage rates of the DTaP-IPV/Hib vaccine,from 1 to 4 doses,were 24.4%,20.7%,18.5%,and 16.0%,respectively.Caregivers who are concerned about vaccine efficacy[adjusted odds ratio(aOR)=1.53,95%confidence interval(CI):1.30-1.79],the manufacturer(aOR=2.05,95%CI:1.69-2.49),and a simple immunization schedule(aOR=1.26,95%CI:1.04-1.54)are factors associated with a higher likelihood of vaccinating children against DTaP-IPV/Hib.In addition,caregivers in urban areas showed more concern about the vaccine price(P=0.010)and immunization schedule(P=0.022)in regard to vaccinating children.Conclusions The DTaP-IPV/Hib vaccine coverage rate in Hainan Province remains low.Factors such as lower socioeconomi

关 键 词：Early child development Pentavalent Diphtheria-tetanus-acellular pertussis inactivated poliomyelitis and Haemophilus influenzae type B vaccine Vaccination coverage Influencing factor China 

分 类 号：R186[医药卫生—流行病学]