碳氢键活化合成1-氨基吲哚衍生物的研究进展  

Research Progress on Synthesis of 1-aminoindole Derivatives by Activation of Hydrocarbon Bond

作　　者：陈依纯 卢梓淇 石君君 谢吴成 CHEN Yi-chun;LU Zi-qi;SHI Jun-jun;XIE Wu-cheng(School of Environmental&Chemical Engineering,Foshan University,Guangdong Foshan 528000,China)

机构地区：[1]佛山科学技术学院环境与化学工程学院,广东佛山528000

出　　处：《广州化工》2023年第17期1-5,共5页GuangZhou Chemical Industry

摘　　要：1-氨基吲哚衍生物具有多种生物活性,其在生物医药等方面得到了广泛应用,高效安全合成1-氨基吲哚衍生物的方法具有重要的研究价值。近年来,通过碳氢键活化合成1-氨基吲哚衍生物取得了长足进展。本文重点介绍了过渡金属催化C-H键活化与炔烃、烯烃、重氮化合物、叶立德的环化反应合成1-氨基吲哚化合物的最新进展,并对该类化合物绿色合成方法进行了展望。1-aminoindole derivatives have a variety of biological activities,which have been widely used in biomedicine and other fields.The efficient and safe synthesis of 1-aminoindole derivatives has important research value.In recent years,great progress has been made in the synthesis of 1-aminoindole derivatives through the activation of hydrocarbon bonds.The recent progress on the synthesis of 1-aminoindole compounds by the cyclization reaction of transition metal catalyzed C-H bond activation with alkynes,alkenes,diazo compounds and ylides was introduced,and the green synthesis methods of these compounds were prospected.

关 键 词：1-氨基吲哚 合成技术 C-H键活化 过渡金属催化 

分 类 号：O621.3[理学—有机化学]