甲状腺自身免疫性疾病与25(OH)D、PTH水平的相关性  

Correlation of thyroid autoimmune diseases with 25 hydroxyvitamin D and parathyroid hormone levels

作　　者：严凯[1,2] 胡涛[1,2] YAN Kai;HU Tao(The First College of Clinical Medical Science,China Three Gorges University,Yichang,Hubei 443003,China;Department of Nuclear Medicine,Yichang Central People’s Hospital,Yichang,Hubei 443003,China)

机构地区：[1]三峡大学第一临床学院,湖北宜昌443003 [2]宜昌市中心人民医院核医学科,湖北宜昌443003

出　　处：《重庆医学》2023年第S02期31-34,共4页Chongqing medicine

摘　　要：目的探讨自身免疫性甲状腺疾病与甲状旁腺激素(PTH)水平、血清25羟基维生素D[25(OH)D]水平的相关性。方法选取2022年5-8月宜昌市中心人民医院初诊的284例自身免疫性甲状腺疾病患者为研究对象,统计维生素D不足率及甲状旁腺激素(PTH)升高比率,并比较不同性别、年龄、甲状腺功能状态、甲状腺自身抗体与25(OH)D的差异,维生素D水平与PTH水平进行相关性分析。结果自身免疫性甲状腺疾病患者25(OH)D水平为(17.38±5.96)ng/mL,维生素D水平不足者占比97.18%(276/284),男性25(OH)D高于女性,甲状腺自身抗体与25(OH)D水平无相关性(P>0.05)。自身免疫性甲状腺疾病PTH升高比例9.15%(26/284),升高组PTH平均水平(122.5±35.2)pg/mL。PTH与25(OH)D呈负相关(r=-0.200)。不同甲状腺功能状态25(OH)D、PTH水平比较,差异有统计学意义(P<0.05)。结论对自身免疫甲状腺疾病高风险患者应及时进行维生素D、PTH的监测和干预。Objective To investigate the correlation between autoimmune thyroid disease and the level of parathyroid hormone(PTH)and serum 25 hydroxyvitamin D[25(OH)D]Methods A total of 284 patients with autoimmune thyroid disease newly diagnosed in Yichang Central People’s Hospital from May to August 2022 were selected as the study objects.The rate of vitamin D deficiency and the rate of increased parathyroid hormone(PTH)were calculated,and the differences between sex,age,thyroid function status,thyroid autoantibodies and 25(OH)D were compared.The correlation between vitamin D level and PTH level was analyzed Results The level of 25(OH)D in patients with autoimmune thyroid diseases was(17.38±5.96)ng/mL,97.18%(276/284)patients had insufficient vitamin D level.The 25(OH)D level in males was higher than that in females,there was no correlation between thyroid autoantibodies and 25(OH)D level(P>0.05).The proportion of PTH increase in autoimmune thyroid diseases was 9.15%(26/284),the average level of PTH in the elevated group was(122.5±35.2)pg/mL.PTH was negatively correlated with 25(OH)D(r=-0.200).There were significant differences in 25(OH)D and PTH levels among different thyroid function states(P<0.05).Conclusion Vitamin D and PTH monitoring and intervention should be carried out in time for patients at high risk of autoimmune thyroid disease.

关 键 词：自身免疫性甲状腺疾病 25羟基维生素D 甲状旁腺激素 相关性 

分 类 号：R581[医药卫生—内分泌]