醒脑静注射液联合尼莫地平注射液对脑出血术后患者颅内血流及康复效果的影响  

Effect of Xingnaojing injection combined with nimodipine injection on intracranial blood flow and rehabilitation effect in patients with cerebral hemorrhage after operation

作　　者：郝胜果 王基想 吴文香 杨帮国 HAO Shengguo;WANG Jixiang;WU Wenxiang;YANG Bangguo(Department of Neurosurgery,Hospital 302 Attached to Guizhou Aviation Group,Guizhou Province,Anshun 561000,China)

机构地区：[1]中国贵航集团三○二医院神经外科,贵州省安顺市561000

出　　处：《临床合理用药杂志》2024年第2期11-14,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察醒脑静注射液联合尼莫地平注射液对脑出血术后患者颅内血流及康复效果的影响。方法选取2020年1月—2021年12月中国贵航集团三○二医院收治的脑出血术后患者100例,采用随机数字表法分为联合组(n=50)和单一组(n=50)。2组均接受脑出血术后常规治疗,单一组在常规治疗基础上加用尼莫地平注射液治疗,联合组在单一组基础上加用醒脑静注射液治疗,2组均持续治疗2周。比较2组治疗前后颅内血流指标(大脑中动脉、基底动脉血流速度)、血清神经损伤指标[神经特异性烯醇酶(NSE)、胶质纤维酸性蛋白(GFAP)],疗程结束时与随访1个月后美国国立卫生研究院卒中量表(NIHSS)评分、脑卒中专门化生活质量量表(SS-QOL)评分及不良反应。结果治疗2周后,2组大脑中动脉、基底动脉血流速度均大于治疗前,且联合组大于单一组(P<0.01);2组NSE、GFAP水平均低于治疗前,且联合组低于单一组(P<0.01)。随访1个月后,2组NIHSS评分低于疗程结束时,SS-QOL评分高于疗程结束时,且联合组低/高于单一组(P<0.01)。治疗期间2组均未见明显不良反应,联合组与单一组不良反应总发生率比较差异无统计学意义(12.00%vs.6.00%,χ^(2)=1.099,P=0.295)。结论醒脑静注射液联合尼莫地平注射液对脑出血术后患者的康复效果较好,可促进颅内血流恢复,减轻脑组织缺血缺氧性损伤,安全性较高。Objective To observe the effect of Xingnaojing injection combined with nimodipine injection on intracranial blood flow and rehabilitation effect in patients with cerebral hemorrhage after operation.Methods A total of 100 patients with intracerebral hemorrhage treated in the Hospital 302 Attached to Guizhou Aviation Group from January 2020 to December 2021 were selected and randomly divided into the combined group(n=50)and the single group(n=50).The single group was treated with nimodipine injection on the basis of conventional treatment,and the combined group was treated with Xingnaojing injection on the basis of the single group.Two groups were treated for 2 weeks.The changes in intracranial blood flow indicators(blood flow velocities of middle cerebral artery and basilar artery)and serum nerve injury indicators[neuron specific enolase(NSE),glial fibrillary acidic protein(GFAP)]were compared between the two groups before and after treatment.At the end of the course of treatment and after 1 month of follow-up,the National Institutes of Health Stroke Scale(NIHSS)and Stroke Specific Quality of Life Scale(SS-QOL)were observed in the two groups.The differences in incidence rates of adverse drug reactions of the two groups were analyzed during treatment.Results After 2 weeks of treatment,the blood flow velocities of middle cerebral artery and basilar artery in two groups were significantly enhanced,and the above indicators in combined group were significantly higher than those in single group(P<0.01).The levels of NSE and GFAP in two groups were significantly decreased after treatment,and the above levels in combined group were significantly lower than those in single group(P<0.01).After 1 month of follow-up,the NIHSS scores of two groups were lower than those at the end of the course,and the SS-QOL scores of two groups were higher than those at the end of the course,and the above indicators in combined group were lower/higher than those in single group(P<0.01)During the treatment period,no obvious adverse reactions w

关 键 词：脑出血术后 醒脑静注射液 尼莫地平注射液 颅内血流 康复效果 

分 类 号：R651.1[医药卫生—外科学]