理中通络化浊汤联合脐灸治疗脾胃虚寒痰湿瘀阻型慢性胃炎的临床效果及安全性  

Clinical effect and safety of Lizhong Tongluo Huazhuo decoction combined with umbilical moxibustion in the treatment of chronic gastritis of spleen stomach deficiency cold phlegm dampness stasis type

作　　者：黄钟琦 HUANG Zhongqi(Dexing Traditional Chinese Medicine Hospital,Jiangxi Province,Dexing 334213,China)

机构地区：[1]江西省德兴市中医院,334213

出　　处：《临床合理用药杂志》2024年第2期19-22,26,共5页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察理中通络化浊汤联合脐灸治疗脾胃虚寒痰湿瘀阻型慢性胃炎的临床效果及安全性。方法选取2019年1月—2021年1月德兴市中医院收治的脾胃虚寒痰湿瘀阻型慢性胃炎患者100例,采用随机数字表法分为试验组和对照组,每组50例。对照组采用常规西药(奥美拉唑+甲硝唑+阿莫西林+胶体果胶铋)治疗,试验组在此基础上实施理中通络化浊汤联合脐灸治疗,2组均连续治疗2周观察疗效,再决定是否继续用药,治疗时间≤6周。比较2组患者治疗效果,治疗前后胃肠功能评分、血清炎性因子、中医证候积分,不良反应及停药6个月后幽门螺杆菌转阴率、病症复发率。结果试验组患者治疗总有效率为92.00%,高于对照组的74.00%(χ^(2)=5.741,P=0.016);2组治疗后胃脘部胀痛、脘腹胀满、胸闷、嗳气及两肋胀满评分,血清白介素-1β、白介素-6和血清三叶因子3水平,大便溏泄、食欲减退、舌诊脉象、少气懒言、神疲乏力、腹部喜按及总积分均较治疗前降低,且试验组低于对照组(P均<0.01);试验组不良反应总发生率低于对照组(2.00%vs.16.00%,χ^(2)=4.396,P=0.036);试验组患者幽门螺杆菌转阴率明显高于对照组(96.00%vs.70.00%,χ^(2)=11.977,P=0.001),病症复发率低于对照组(2.00%vs.16.00%,χ^(2)=4.396,P=0.036)。结论理中通络化浊汤联合脐灸治疗脾胃虚寒痰湿瘀阻型慢性胃炎可显著提高临床疗效,可改善患者胃肠功能,调节炎性因子水平,明显改善症状,不良反应发生率低,且可提高幽门螺杆菌转阴率,降低病症复发率。Objective To observe the clinical effect and safety of Lizhong Tongluo Huazhuo decoction combined with umbilical moxibustion in the treatment of chronic gastritis of spleen stomach deficiency cold phlegm dampness stasis type.Methods A total of 100 patients with chronic gastritis of spleen stomach deficiency cold phlegm dampness stasis type admitted to Dexing Traditional Chinese Medicine Hospital from January 2019 to January 2021 were selected and randomly divided into experimental group and control group,with 50 cases in each group.The control group was treated with conventional Western Medicine(omeprazole+metronidazole+amoxicillin+colloidal bismuth pectin),while the experimental group was treated with Lizhong Tongluo Huazhuo decoction combined with umbilical moxibustion on the basis of the control group.Two groups were treated for 2 weeks to observe the curative effect,and then decide whether to continue the medication.The treatment time was≤6 weeks.The treatment effect,gastrointestinal function score,serum inflammatory factors,TCM syndrome score,adverse reactions,negative conversion rate of Helicobacter pylori and disease recurrence rate six months after drug withdrawal were compared between the two groups.Results The total effective rate of the experimental group was 92.00%,which was higher than 74.00%of the control group(χ^(2)=5.741,P=0.016);After treatment,the scores of epigastric distension,abdominal distension,chest tightness,belching and bilateral rib distension,the levels of serum interleukin-1β,interleukin-6 and serum trefoil factor 3,loose stool,anorexia,tongue pulse,less breath and lazy words,mental fatigue,abdominal massage and total score were lower than those before treatment,and the experimental group was lower than that of the control group(P<0.01);The total incidence of adverse reactions in the experimental group was lower than that in the control group(2.00%vs.16.00%,χ^(2)=4.396,P=0.036);The negative conversion rate of Helicobacter pylori in the experimental group was significantly higher

关 键 词：慢性胃炎 脾胃虚寒痰湿瘀阻型 理中通络化浊汤 脐灸 胃肠功能 炎性因子 安全性 

分 类 号：R259[医药卫生—中西医结合]