肝硬化疾病诊断中的生化检验项目应用价值分析  

Analysis of the Application Value of Biochemical Test Items in the Diagno⁃sis of Liver Cirrhosis Disease

作　　者：左晶 ZUO Jing(Department of Laboratory,Cangzhou Nandagang Hospital,Cangzhou,Hebei Province,061103 China)

机构地区：[1]沧州市南大港医院检验科,河北沧州061103

出　　处：《系统医学》2023年第22期64-67,共4页Systems Medicine

摘　　要：目的 研究肝硬化疾病中应用生化检验项目诊断的效果。方法 回顾性分析2022年5月—2023年5月沧州市南大港医院收治的50例肝硬化疾病患者的临床资料并设为患病组,另择取同期50例健康体检者设为参照组,均行生化检验项目诊断,分析两组诊断结果。结果 患病组总胆红素(total bilirubin, TBIL)(82.54±10.52)μmol/L高于参照组(10.56±1.65)μmol/L,差异有统计学意义(t=47.797,P<0.05);患病组丙氨酸转氨酶(alanine aminotransferase, ALT)、天冬氨酸转氨酶(aspartate aminotransferase, AST)、碱性磷酸酶(alkaline phosphatase, ALP)、直接胆红素(direct bilirubin, DBIL)、r-谷氨酰转肽酶(r-glutamyltranspeptidase, r-GT)、Ⅳ型胶原(type IV collagen,Ⅳ-C)、血清透明质酸(serum hyaluronic acid, HA)、Ⅲ型前胶原(type III procollagen, PC-Ⅲ)、层粘连蛋白(laminin, LN)指标高于参照组,胆碱酯酶(cholinesterase, CHE)、总蛋白(total protein, TP)、白蛋白(albumin, ALB)指标低于参照组,差异有统计学意义(P<0.05);晚期患者的TBIL、ALT、AST、ALP、DBIL、r-GT、Ⅳ-C、HA、PC-Ⅲ、LN指标高于早期与中期患者,CHE、TP、ALB低于早期与中期患者,差异有统计学意义(P<0.05)。结论 生化检验项目诊断肝硬化疾病患者可明确病情、了解疾病严重程度,为疾病诊疗提供数据,改善预后效果。Objective To study the effect of application of biochemical test items in the diagnosis of liver cirrhosis dis-eases.Methods The clinical data of 50 patients with cirrhosis admitted to Cangzhou Nandagang Hospital from May 2022 to May 2023 were retrospectively analyzed and set as the diseased group.Another 50 health checkups in the same period of physical examination were selected as the reference group.Biochemical tests were performed to diag-nose the results of the two groups.Results Total bilirubin(TBIL)of the diseased group was(82.54±10.52)μmol/L higher than that of the reference group(10.56±1.65)μmol/L,and the difference was statistically significant(t=47.797,P<0.05).The indexes of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),direct bilirubin(DBIL),r-glutamyltranspeptidase(r-GT),type IV collagen(IV-C),serum hyaluronic acid(HA),type III procollagen(PC-III),and laminin(LN)in the diseased group were higher than those of the reference group,and the indexes of cholinesterase(CHE),total protein(TP),and albumin(ALB)in the diseased group were lower than those of the reference group,the differences were statistically significant(P<0.05).The indexes of TBIL,ALT,AST,ALP,DBIL,r-GT,IV-C,HA,PC-III,LN in advanced stage patients were higher than those in early and intermediate stage patients,and the indexes of CHE,TP,ALB in advanced stage patients were lower than those in early and intermediate stage patients,the differences were statistically significant(P<0.05).Conclusion Biochemical test items to diagnose patients with liver cirrhosis disease can clarify the condition,understand the severity of the dis-ease,provide data for the diagnosis and treatment of the disease,improve the prognosis effect.

关 键 词：肝硬化疾病 生化检验项目 疾病诊断 诊断价值 

分 类 号：R446.1[医药卫生—诊断学]