心脏淀粉样变相关冠状动脉微血管病变的研究进展  

Research progress of cardiac amyloidosis related coronary microvascular dysfunction

作　　者：马佳琪 郑柳颖 耿婕 Ma Jiaqi;Zheng Liuying;Geng Jie(Department of Cardiology,Clinical School of Thoracic,Tianjin Medical University,Tianjin 300070,China;Department of Cardiology,Chest Hospital,Tianjin University,Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care,Tianjin Municipal Science and Technology Bureau,Tianjin 300051,China)

机构地区：[1]天津医科大学胸科临床学院心血管内科,天津300070 [2]天津大学胸科医院心血管内科,天津市急危重症重点实验室,天津市科学技术局,天津300051

出　　处：《中国医学前沿杂志（电子版）》2023年第12期64-69,共6页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：天津市医学重点学科(专科)建设项目(TJYXZDXK-055B);天津市科技计划项目(22JCZDJC00580)。

摘　　要：心脏淀粉样变(cardiac amyloidosis,CA)是由于不溶于水的纤维样蛋白沉积在心肌间质,导致心功能障碍的一组疾病。近年来,国内外报道了大量心外膜冠状动脉血管未见异常的CA患者以劳力性心绞痛为表现就诊。冠状动脉微循环功能障碍(coronary microvascular dysfunction,CMD)存在于CA患者中,但其发病机制较为复杂,目前尚未阐明。本文结合既往的文献资料对CA相关的CMD发病机制做一综述,探讨其可能的治疗靶点。Cardiac amyloidosis(CA)is a family of diseases in which water-insoluble fibrillar proteins are deposited in the interstitium of the heart,leading to cardiac dysfunction.In recent years,the symptoms of exertional angina have been reported at home and abroad in many patients with CA without obstructive epicardial coronary artery disease.Coronary microvascular dysfunction(CMD)has been confirmed in patients with CA,but the pathogenesis is complex and remains unclear.Based on the previous literature,this paper reviewed the pathogenesis of CA related CMD and discussed its possible therapeutic targets.

关 键 词：心脏淀粉样变 冠状动脉微循环功能障碍 劳力性心绞痛 发病机制 

分 类 号：R597.2[医药卫生—内科学]