Rapid Access to Free Phenols by Photocatalytic Acceptorless Dehydrogenation of Cyclohexanones at Room Temperature  

作　　者：Lin Min Jiani Lin Wei Shu 

机构地区：[1]Shenzhen Grubbs Institute,Department of Chemistry,and Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,Guangdong,518055 China

出　　处：《Chinese Journal of Chemistry》2023年第21期2773-2778,共6页中国化学（英文版）

基　　金：Financial support from NSFC(21971101 and 22171127);Guangdong Basic and Applied Basic Research Foundation(2022A1515011806);Department of Education of Guangdong Province(2021KTSCX106);Guangdong Province Graduate Education Innovation Program(2022JGXM054);The Pearl River Talent Recruitment Program(2019QN01Y261);Shenzhen Science and Technology Innovation Committee(JCYJ20220519201425001);GuangdonggProvincialKeyLaboratoryofCatalysis(2020B121201002)is sincerely acknowledged.We acknowledge the assistance of SUsTech Core Research Facilities.

摘　　要：Phenols are ubiquitous substructures in natural products and bioactive compounds.However,practical methods for the direct construction of phenols under mild conditions remain challenging.Herein,a photocatalytic acceptorless hydrogen-evolution aromatization of cyclohexanones or cyclohexenones at room temperature has been developed.The reaction features the visible-light and cobalt co-catalyzed sequential dehydrogenation of in-situ formed enol silyl ethers,which are regarded as a challenging process.This operationally simple method enables the synthesis of a series of phenols with diverse substitution patterns from cyclohexanones or cyclohexenones.Moreover,diverse substituted 1,2-,1,3-,and 1,4-benzenediols were obtained from cyclohexanediones,providing a general and straightforward method for the synthesis of phenols from simple starting materials under mild conditions.

关 键 词：PHENOLS PHOTOCATALYSIS DEHYDROGENATION CYCLOHEXANONES Cobalt catalysis RADICALS 

分 类 号：O62[理学—有机化学]