卵巢癌患者腹腔镜术后外周血IL-37、HK10、SMRP水平监测意义研究  

Study on the significance of monitoring peripheral blood interleukin-37,human kallikrein 10 and soluble mesothelin-related peptide levels in ovarian cancer patients after laparoscopic surgery

作　　者：蒋冬 杨旭 帅旭 JIANG Dong;YANG Xu;SHUAI Xu(Department of Obstetrics and Gynecology,Chengdu Fifth People's Hospital,Chengdu 611130,Sichuan,China)

机构地区：[1]成都市第五人民医院妇产科,成都611130

出　　处：《中国性科学》2024年第1期98-102,共5页Chinese Journal of Human Sexuality

基　　金：四川省科技计划项目(苗子工程项目)(22MZGC0259)。

摘　　要：目的探究卵巢癌腹腔镜根治术后外周血白介素-37(IL-37)、人激肽释放酶10(HK10)、可溶性间皮素相关肽(SMRP)水平与疗效及复发的相关性。方法选取2020年1月至2021年10月成都市第五人民医院收治的106例卵巢癌患者作为研究对象,设为研究组。另选取同期100例卵巢良性肿瘤患者作为对照组。比较两组血清IL-37、HK10、SMRP水平,比较研究组腹腔镜根治术不同疗效、复发情况患者术后血清IL-37、HK10、SMRP水平,分析血清IL-37、HK10、SMRP水平预测术后复发的价值。结果研究组术前血清IL-37、HK10、SMRP水平均高于对照组(P<0.05);研究组完全缓解患者术后7 d、化疗后血清IL-37、HK10、SMRP水平均低于部分缓解患者,部分缓解患者均低于稳定患者,稳定患者均低于进展患者(P<0.05);研究组复发患者术后7 d、化疗后血清IL-37、HK10、SMRP水平均高于未复发患者(P<0.05);化疗后血清IL-37、HK10、SMRP水平预测卵巢癌腹腔镜根治术后复发的曲线下面积(AUC)分别为0.801、0.768、0.742,联合预测的AUC最大,为0.910。结论卵巢癌腹腔镜根治术后血清IL-37、HK10、SMRP水平与疗效密切相关,且化疗后各指标联合在预测术后复发方面具有较高的预测效能。Objective To investigate the correlation of interleukin-37(IL-37),human kallikrein 10(HK10),and soluble mesothelin-related peptide(SMRP)in peripheral blood after laparoscopic radical surgery for ovarian cancer with the curative efficacy and recurrence of the disease.Methods A total of 106 ovarian cancer patients admitted to the Chengdu Fifth People's Hospital from January 2020 to October 2021 were selected as the research subjects and set as study group.Another 100 patients from same period with ovarian benign tumors were selected as the control group.The levels of serum IL-37,HK10,and SMRP were compared between the two groups.The serum levels of IL-37,HK10 and SMRP in patients with different therapeutic effects and recurrence after laparoscopic radical surgery in the study group were compared,and the value of serum IL-37,HK10,and SMRP levels in predicting postoperative recurrence was analyzed.Results The levels of serum IL-37,HK10 and SMRP in the study group were higher than those in the control group before surgery(P<0.05);the levels of serum IL-37,HK10,and SMRP in patients with complete remission in the study group were lower than those in patients with partial remission 7 days after surgery and after chemotherapy,and the levels of serum IL-37,HK10,and SMRP in patients with partial remission were lower than those in patients with stable disease,and the levels of serum IL-37,HK10,and SMRP in patients with stable disease were lower than those in patients with progressive disease(P<0.05);the levels of serum IL-37,HK10,and SMRP in patients with recurrence in the study group were higher than those in patients without recurrence 7 days after surgery and after chemotherapy(P<0.05);the area under the curve(AUC)of serum IL-37,HK10 and SMRP levels after chemotherapy in predicting the recurrence of ovarian cancer after laparoscopic radical surgery were 0.801,0.768 and 0.742,respectively,and the combined prediction was the largest,which is 0.910.Conclusions The levels of serum IL-37,HK10 and SMRP after laparoscopic radica

关 键 词：卵巢癌 腹腔镜根治术 白介素-37 人激肽释放酶10 可溶性间皮素相关肽 

分 类 号：R711[医药卫生—妇产科学]