重组人粒细胞集落刺激因子联合阿司匹林对不明原因不孕症患者子宫内膜容受性的影响  

Effect of recombinant human granulocyte colony stimulating factor combined with aspirin on endometrial receptivity in patients with unexplained infertility

作　　者：王振燕 李娅 麻莉 WANG Zhenyan;LI Ya;MA Li(Department of Obstetrics and Gynecology,Jinzhou Medical University Rocket Army Characteristic Medical Center Graduate Training Base,Beijing 110000,China;Department of Obstetrics and Gynecology,Hebei Yanda Hospital,Langfang 065201,Hebei,China;Department of Obstetrics and Gynecology,Beijing Meizhong Airui Cancer Hospital,Beijing 100070,China)

机构地区：[1]锦州医科大学火箭军特色医学中心研究生培养基地妇产科,北京110000 [2]河北燕达医院妇产科,河北廊坊065201 [3]北京美中爱瑞肿瘤医院妇产科,北京100070

出　　处：《中国性科学》2024年第1期102-105,共4页Chinese Journal of Human Sexuality

基　　金：河北省医学科学研究课题(20211736)。

摘　　要：目的探讨重组人粒细胞集落刺激因子(rhG-CSF)联合阿司匹林对不明原因不孕症患者子宫内膜容受性的影响。方法回顾性分析2020年10月至2022年10月河北燕达医院收治的97例不明原因不孕症患者的临床资料。根据治疗方式分为常规组(n=48,采用阿司匹林治疗)和联合组(n=49,采用rhG-CSF联合阿司匹林治疗)。比较两组治疗前后的子宫内膜厚度、子宫血流灌注指标[子宫动脉阻力指数(RI)、搏动指数(PI)、收缩期流速与舒张期流速比值(S/D)],比较两组的妊娠结局。结果治疗后,联合组子宫内膜厚度大于常规组,差异具有统计学意义(P<0.05)。治疗后,两组RI、PI及S/D值均降低,且联合组低于常规组,差异具有统计学意义(P<0.05)。治疗后,联合组生化妊娠率、临床妊娠率均高于常规组,差异具有统计学意义(P<0.05)。结论rhG-CSF联合阿司匹林治疗不明原因不孕症患者,可提高其的子宫内膜容受性,改善子宫血流灌注,有效提高妊娠率。Objective To investigate the effect of recombinant human granulocyte colony stimulating factor(rhG-CSF)combined with aspirin on endometrial receptivity in patients with unexplained infertility.Methods Retrospective analysis was conducted on the clinical data of 97 patients with unexplained infertility admitted to Hebei Yanda Hospital from October 2020 to October 2022.They were divided into a conventional group(48 cases treated with aspirin)and a combination group(49 cases treated with rhG-CSF combined with aspirin)based on their treatment methods.Endometrial thickness,uterine blood flow perfusion indexes[uterine artery resistance index(RI),pulsatility index(PI),systolic velocity and diastolic velocity ratio(S/D)]before and after treatment were compared between the two groups.The pregnancy outcomes were compared in the two groups.Results After treatment,the endometrial thickness in the combination group was greater than that in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the RI,PI,and S/D values of both groups decreased,and the combination group was lower than the conventional group,the difference is statistically significant(P<0.05).After treatment,the biochemical pregnancy rate and clinical pregnancy rate in the combination group were higher than those in the conventional group,the difference is statistically significant(P<0.05).Conclusions The combination of rhG-CSF and aspirin in the treatment of patients with unexplained infertility can improve the endometrial receptivity,improve uterine blood flow perfusion,and effectively increase the pregnancy rate.

关 键 词：不明原因不孕症 子宫内膜容受性 重组人粒细胞集落刺激因子 阿司匹林 临床妊娠 

分 类 号：R711[医药卫生—妇产科学]