血清AMH、Hcy水平诊断PCOS价值及与不孕治疗结局关系  

Diagnostic value of the serum anti Mullerian hormone and homocysteine levels of infertility women for their polycystic ovary syndrome and their correlation with the treatment outcomes for infertility

作　　者：高慧双 王俊文[1] 宁永忠 赫琪 GAO Huishuang;WANG Junwen;NING Yongzhong;HE Qi(Beijing Chuiyangliu Hospital,Beijing,100021;Inner Mongolia Autonomous Region People's Hospital,Hohhot)

机构地区：[1]北京市垂杨柳医院,100022 [2]内蒙古自治区人民医院

出　　处：《中国计划生育学杂志》2024年第1期191-194,共4页Chinese Journal of Family Planning

摘　　要：目的:分析血清抗缪勒氏管激素(AMH)和同型半胱氨酸(Hcy)水平诊断多囊卵巢综合征(PCOS)价值及与不孕治疗结局关系。方法:选择北京市垂杨柳医院和内蒙古自治区人民医院2021年9月-2022年3月收治的81例PCOS和卵巢功能减退(DOR)不孕患者临床资料,其中PCOS 42例为PCOS组,DOR 39例为DOR组,选择健康体检女性40例为对照组;比较3组血清AMH和Hcy水平,采用logistics回归模型分析2指标联合应用诊断PCOS模型,采用Spearman相关性检验分析AMH和Hcy水平与PCOS患者不孕治疗1年后结局关系。结果:PCOS组、DOR组、对照组血清AMH和Hcy水平存在差异,其中PCOS组AMH和Hcy水平最高(P<0.05);采用logistics回归模型构建的PCOS诊断模型为Log(P)=0.675×AMH+0.701×Hcy+0.644(P<0.05);AMH和Hcy联合应用诊断PCOS的曲线下面积(0.970)高于AMH(0.850)、Hcy(0.895)单独应用(P<0.05);PCOS组随访1年,妊娠患者血清AMH(12.03±1.21 ng/ml)和Hcy(11.79±1.31μmol/L)水平均低于未妊娠患者(15.12±2.31 ng/ml、14.11±1.89μmol/L),且二者水平均与PCOS患者不孕妊娠结局呈正相关(均P<0.05)。结论:血清AMH和Hcy水平联合联合检测有效诊断PCOS,且两指标与PCOS患者治疗不孕结局呈正相关。Objective:To analyze the diagnostic wvalue of serum anti Mullerian hormone(AMH)and homocysteine(Hey)levels of infertility women for their polycystic ovary syndrome(PCOS),and to study the correlation between the AMH and Hcy levels of the women and their ifrtility outcomes.Methods:The clinical data of 81 women with PCOS or with diminuted ovarian reserve(DOR)admitted to hospital from September 2021 to March 2022 were selected as the research objects,including 42 women with PCOS in group A and 39 women with DOR in group B.40 healthy women were selected in group C during the same time.The serum levels of AMH and Hcy of the women were compared among the three groups.Logistics regression model was used to establish the diagnostic model for PCOS.Spearman correlation test was used to analyze the correlation between the AMH and Hcy levels of the women with PCOS and their outcomes after 1 year of treating their ifertility.Results:The serum AMH and Hey levels of the women were significantly different among the three groups,and which of the women in group A were the highest(P<0.05).The diagnostic model of PCOS constructed by logistics regression model was Log(P)-0.675X AMH+0.701X Hey+0.644(P<0.05).The area under the curve(AUC)of the combined AMH and Hcy levels of the women for diagnosing their PCOS was 0.970,which was significantly higher than that(0.850)of the AMH level or that(0.895)of the Hey level alone(P<0.05).In group A.the women were fllowved up for 1 year,the levels of serum AMH(12.03±1.21 ng/ml)and Hcy(11.79±1.31μmol/L)of the women with pregnancy were significantly lower than those(15.12±2.31 ng/ml and 14.11±1.89μmol/L)of the women without pregnancy,and the levels of serum AMH and Hcy of the infertility women with PCOS were positively correlated with their pregnancy outcomes(all P<0.05).Conclusion:The combined AMH and Hey levels of the women for diagnosing their PCOS has efect and both the serum AMH level and Hey level of the infertility women with PCOS are positively correlated with their pregnancy outcomes.

关 键 词：多囊卵巢综合征 不孕 抗缪勒氏管激素 同型半胱氨酸 诊断模型 治疗不孕结局关系 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]