胃癌术后患者衰弱与首次口服化疗期间症状群的相关性研究  

Correlation between frailty and symptom clusters during first oral chemotherapy in postoperative patients with gastric cancer

作　　者：刘艳[1] 杨燕[2] 徐静娟[3] 徐春兰[1] 顾迪[1] Liu Yan;Yang Yan;Xu Jingjuan;Xu Chunlan;Gu Di(Department of Oncology,First People′s Hospital of Changzhou,Changzhou 213000,China;Department of Respiratory,First People′s Hospital of Changzhou,Changzhou 213000,China;Department of Outpatient Office,First People′s Hospital of Changzhou,Changzhou 213000,China)

机构地区：[1]常州市第一人民医院肿瘤科,常州213000 [2]常州市第一人民医院呼吸科,常州213000 [3]常州市第一人民医院门诊办公室,常州213000

出　　处：《中国实用护理杂志》2023年第35期2782-2788,共7页Chinese Journal of Practical Nursing

摘　　要：目的了解胃癌术后患者的衰弱现状,并探究其对术后首次口服化疗期间症状群的影响,为肿瘤患者的症状管理提供理论指导。方法采用横断面调查法,方便抽样法选取2021年10月至2022年10月在常州市第一人民医院肿瘤科首次接受口服化疗的133例胃癌术后患者为研究对象,采用一般资料调查表和衰弱表型评估工具对患者化疗前基线资料进行调查,采用安德森消化道癌症症状评估量表对化疗第2天和化疗第14天的症状进行评估。结果胃癌术后患者中衰弱发生率为48.9%(65/133)。化疗第2天存在4个症状群,分别为情绪症状群、消化道症状群、病感症状群和神经症状群,累计方差贡献率为61.20%;化疗第14天增加了胃癌特异性症状群,共形成5个症状群,累计方差贡献率为63.90%。化疗第2天,衰弱对情绪症状群、消化道症状群、神经症状群的影响有统计学意义(t=3.52、2.66、5.48,均P<0.05),分别解释其症状群变异度的7.2%、4.1%、15.1%;化疗第14天,衰弱对情绪症状群、消化道症状群、神经症状群的影响仍有统计学意义(t=3.41、5.47、4.06,均P<0.05),分别解释其症状群变异度的7.1%、13.2%、9.6%。结论胃癌术后患者衰弱发生率处于较高水平,衰弱的患者口服化疗期间情绪症状群、消化道症状群和神经症状群都更为严重。Objective To understand the status of frailty in postoperative gastric cancer patients and to explore its influence on symptom groups during the initial oral chemotherapy.Provide theoretical guidance for symptom management of cancer patients.Methods A total of 133 postoperative gastric cancer patients who received initial oral chemotherapy were selected as subjects by cross section survey from Octomber 2021 to Octomber 2022 in Department of Oncology,First People′s Hospital of Changzhou by couvenient sampling method.Baseline data of patients before chemotherapy were investigated by general data questionnaire and Frailty Phenotype.Symptoms on the 2nd and 14th day of chemotherapy were investigated by M.D.Anderson Symptom Inventory-Gastrointestinal Cancer Module.Results The incidence of frailty in postoperative gastric cancer patients was 48.9%(65/133).On the 2nd day of chemotherapy,there were four symptom clusters,namely emotional symptom cluster,gastrointestinal symptom cluster,disease related symptom cluster and neurological symptom cluster,and the cumulative variance contribution rate was 61.20%.On the 14th day of chemotherapy,there were five symptom clusters after gastric cancer specific symptom cluster appeared.and the cumulative variance contribution rate was 63.90%.On the 2nd day of chemotherapy,frailty had statistical significance on emotional symptom cluster,gastrointestinal symptom cluster andneurological symptom cluster(t=3.52,2.66,5.48,all P<0.05),which explained 7.2%,4.1%and 15.1%of symptom group severity,respectively.On the 14th day of chemotherapy,frailty still had statistical significance on emotional symptom cluster,gastrointestinal symptom cluster and neurological symptom cluster(t=3.41,5.47,4.06,all P<0.05),which explained 7.1%,13.2%and 9.6%of symptom group severity,respectively.Conclusions The incidence of frailty in patients with postoperative gastric cancer was at a relatively high level.The emotional symptom cluster,gastrointestinal symptom cluster,and neurological system related symptom clu

关 键 词：胃肿瘤 口服化疗 症状群 衰弱 

分 类 号：R473.73[医药卫生—护理学]