多囊卵巢综合征患者卵巢颗粒细胞胰岛素抵抗的相关信号通路  

Pathways of Insulin Resistance in Ovarian Granulosa Cells of Polycystic Ovary Syndrome Patients

作　　者：任露露 任文超[2] 张晓轩 任春娥(审校)[2] REN Lu-lu;REN Wen-chao;ZHANG Xiao-xuan;REN Chun-e(School of Clinical Medicine,Weifang Medical University,Weifang 261053,Shandong Province,China;Affiliated Hospital of Weifang Medical University,Weifang 261035,Shandong Province,China)

机构地区：[1]山东省潍坊医学院临床医学院,261053 [2]山东省潍坊医学院附属医院

出　　处：《国际生殖健康／计划生育杂志》2024年第1期32-37,共6页Journal of International Reproductive Health/Family Planning

基　　金：山东省医药卫生科技发展计划项目(202005030464)。

摘　　要：胰岛素抵抗(insulin resistance,IR)与多囊卵巢综合征(polycystic ovary syndrome,PCOS)的发生发展有关,而与IR相关的胰岛素信号通路异常会引起卵巢局部代谢紊乱,进而影响卵泡发育及卵子质量。PCOS卵巢颗粒细胞中胰岛素作用的经典通路,包括磷脂酰肌醇3激酶(phosphoinositide 3-kinase,PI3K)/蛋白激酶B(protein kinase B,Akt)通路和丝裂原激活的蛋白激酶(mitogen-activated protein kinase,MAPK)/细胞外信号调节激酶(extracellular signal-regulated kinase,ERK)通路;与炎症相关的通路包括Toll样受体(Toll-like receptor,TLR)/核因子κB(nuclear factor-κB,NF-κB)通路等;氧化应激相关通路包括核转录因子红系2相关因子2(nuclear factor-erythroid 2-related factor 2,Nrf2)/血红素加氧酶-1(heme oxygenase-1,HO-1)途径和GTP酶免疫相关蛋白7(GTPase of immunity-associated protein 7,GIMAP7)/音猬因子(sonic hedgehog,SHH)途径;与脂质代谢相关的通路如激活转录因子4(activating transcription factor 4,ATF4)通路等。明确PCOS患者卵巢颗粒细胞中IR相关信号转导通路,增进PCOS病理生理机制的认识,进一步为PCOS的治疗提供新思路。Insulin resistance(IR)is associated with the genesis and development of polycystic ovary syndrome(PCOS).The abnormity of insulin-related signaling pathways causes metabolism disorder,which affects follicle development and quality.In ovarian granulosa cells of PCOS,the classical pathways of insulin include phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)and mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase(ERK).The pathways related with inflammation include Toll-like receptor(TLR)/nuclear factor-κB(NF-κB),and the pathways of oxidative stress include nuclear factor-erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)and GTPase of immunity-associated protein 7(GIMAP7)/sonic hedgehog(SHH).There are multiple pathways related with metabolism,such as the lipid metabolism-related pathway of activating transcription factor 4(ATF4).Therefore,clarifying the IR-related signal transduction pathway and molecular mechanism in ovarian granulosa cells of PCOS patients can supplement the knowledge of PCOS pathogenesis,and further provide new ideas for the treatment of PCOS.

关 键 词：多囊卵巢综合征 胰岛素抵抗 细胞内信号肽和蛋白质类 信号传导 颗粒细胞 

分 类 号：R711.75[医药卫生—妇产科学]