免疫细胞和免疫因子在子宫内膜癌中的作用  

Effect of Immune Cells and Immune Factors in Endometrial Cancer

作　　者：何玲 蒯丹 张艳芳[1] 田文艳[1] 王颖梅[1] 张慧英(审校)[1] HE Ling;KUAI Dan;ZHANG Yan-fang;TIAN Wen-yan;WANG Ying-mei;ZHANG Hui-ying(Department of Obstetrics and Gynecology,Tianjin Medical University General Hospital,Tianjin Key Laboratory of Female Reproductive Health and Eugenics,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院妇产科,天津市女性生殖健康与优生重点实验室,300052

出　　处：《国际生殖健康／计划生育杂志》2024年第1期83-88,共6页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金(82171629,82172626);天津市医学重点学科(专科)建设项目(TJYXZDXK-031A)。

摘　　要：子宫内膜癌是常见的妇科恶性肿瘤,严重威胁女性的生活质量和生命健康。近年研究显示,在子宫内膜癌免疫微环境中,树突状细胞等免疫细胞与免疫增强因子相互作用可增强抗肿瘤的免疫效应,而肿瘤相关巨噬细胞等免疫细胞与免疫抑制因子通过抑制免疫应答可发挥促肿瘤的免疫效应。综述子宫内膜癌免疫微环境中部分免疫细胞、免疫抑制因子及免疫增强因子的研究进展,为深入研究子宫内膜癌的发病机制及免疫治疗方法提供新思路。Endometrial cancer is a common gynecological malignant tumor,which seriously threatens the quality of life and health of women.Recent studies have shown that in the immune microenvironment of endometrial cancer,the interaction between immune cells such as dendritic cells and immune-enhancing factors can enhance the anti-tumor immune effect,while immune cells such as tumor-associated macrophages and immunosuppressive factors can exert tumor-promoting immune effects by inhibiting immune responses.This article reviews the research progress on the effects of some immune cells,immunosuppressive factors and immune enhancing factors in the immune microenvironment of endometrial cancer,and provides new ideas for further study of the pathogenesis and immunotherapy of endometrial cancer.

关 键 词：子宫内膜肿瘤 肿瘤微环境 免疫细胞 免疫抑制因子 免疫增强因子 

分 类 号：R737.33[医药卫生—肿瘤]