阿奇霉素联合β-内酰胺类抗菌药物治疗小儿细菌性肺炎的效果  

Efficacy of Azithromycin Combined withβ-lactam Antibiotics in the Treatment of Pediatric Bacterial Pneumonia

作　　者：谢静[1] Xie Jing(Guizhou Provincial People's Hospital,Guiyang 550002,Guizhou Province,China)

机构地区：[1]贵州省人民医院,贵州贵阳550002

出　　处：《中外医药研究》2023年第29期57-59,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析阿奇霉素联合β-内酰胺类抗菌药物治疗小儿细菌性肺炎的效果。方法:选取2021年8月—2022年9月贵州省人民医院收治的74例细菌性肺炎患儿作为研究对象,按照随机数字表法分为两组,各37例。对照组采用β-内酰胺抗菌药物治疗,研究组采用阿奇霉素联合β-内酰胺抗菌药物治疗。比较两组临床相关指标、临床疗效及不良反应发生情况。结果:研究组气喘消失时间、体温恢复正常时间、肺部啰音消失时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。研究组治疗有效率高于对照组,差异有统计学意义(P=0.0246)。治疗前,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05);治疗后,两组TNF-α、IL-4、IL-6、hs-CRP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P=0.0470)。结论:阿奇霉素联合β-内酰胺类抗菌药物治疗小儿细菌性肺炎的效果显著,可改善患儿临床症状,加快恢复速度,减轻炎性反应,降低不良反应发生率。Objective:To analyze the effect of azithromycin combined withβ-lactam antibiotics on children with bacterial pneumonia.Methods:A total of 74 children with bacterial pneumonia admitted to Guizhou Provincial People's Hospital from August 2021 to September 2022 were selected as the study objects and divided into two groups according to random number table method,with 37 cases in each group.The control group was treated withβ-lactam antibiotics,and the study group was treated with azithromycin combined withβ-lactam antibiotics.Clinical indicators,clinical efficacy and adverse reactions were compared between the two groups.Results:The disappearance time of asthma,the recovery time of body temperature,the disappearance time of lung rales and the length of hospital stay in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The effective rate of treatment in the study group was higher than that in the control group,and the difference was statistically significant(P=0.0246).Before treatment,there was no significant difference in the levels of tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),interleukin-6(IL-6)and hypersensitive C-reactive protein(hs-CRP)between 2 groups(P>0.05).After treatment,the levels of TNF-α,IL-4,IL-6 and hs-CRP in 2 groups were lower than before treatment,and the study group was lower than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P=0.0470).Conclusion:Azithromycin combined withβ-lactam antibiotics has a remarkable effect in the treatment of pediatric bacterial pneumonia,which can improve the clinical symptoms of children,accelerate the recovery speed,reduce inflammatory reaction and reduce the incidence of adverse reactions.

关 键 词：阿奇霉素 Β-内酰胺类抗菌药物 联合应用 合理性 

分 类 号：R72[医药卫生—儿科]