特应性皮炎患儿IL-17基因多态性及其临床意义  

Genetic polymorphism of IL-17 and its clinical significance in children with atopic dermatitis

作　　者：李珂[1] 朱沙[1] LI Ke;ZHU Sha(School of Basic Medical Science,Zhengzhou University,Henan Province,Zhengzhou 450000,China)

机构地区：[1]郑州大学基础医学院,河南郑州450000

出　　处：《妇儿健康导刊》2023年第24期44-46,共3页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨特应性皮炎(AD)患儿IL-17基因多态性及其临床意义。方法选取2022年1月至12月于郑州大学附属儿童医院治疗的120例AD患儿为AD组,根据病情分为轻症组(n=84)和重症组(n=36),选择同期体检的80例儿童为对照组。采用聚合酶链式扩增反应对目的基因多态性位点进行扩增,明确基因分型。结果AD组IL-17A rs2275913位点A等位基因、IL-17F rs12203582位点A等位基因频率高于对照组(P<0.05)。重症组IL-17A rs2275913位点A等位基因、IL-17F rs12203582位点A等位基因频率高于轻症组(P<0.05)。结论IL-17A rs2275913位点与IL-17F rs12203582位点基因多态性对AD易感性和病情严重程度均有一定影响。Objective To investigate the genetic polymorphism of IL-17 and its clinical significance in children with atopic dermatitis(AD).Methods A total of 120 children with AD treated in the Children’s Hospital Affiliated to Zhengzhou University from January to December 2022 were selected as AD group,and divided into mild group(n=84)and severe group(n=36)according to their disease conditions.A total of 80 children who underwent physical examination during the same period were selected as control group.Polymerase chain amplification was used to amplify the polymorphic loci of the target gene and identify the genotype.Results The frequency of A allele of IL-17A rs2275913 and A allele of IL-17F rs12203582 in AD group was higher than that in control group(P<0.05).The frequency of A allele of IL-17A rs2275913 and A allele of IL-17F rs12203582 in severe group was higher than that in mild group(P<0.05).Conclusion The genetic polymorphism of IL-17A rs2275913 and IL-17F rs12203582 has a certain effect on the susceptibility and severity of AD.

关 键 词：IL-17A IL-17F 基因多态性 特应性皮炎 严重程度 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]