胃黏膜保护剂联合质子泵抑制剂治疗消化性溃疡伴出血的临床效果  

Clinical Effect of Gastric Mucosal Protective Agent Combined with Hydrogen Pump Inhibitors in the Treatment of Peptic Ulcer Bleeding

作　　者：桑腮芳 SANG Sai-fang(Department of Gastroenterology,Huang Jiasi Hospital/Yushan County People's Hospital,Yushan 334700,Jiangxi,China)

机构地区：[1]黄家驷医院/玉山县人民医院消化内科,江西玉山334700

出　　处：《医学信息》2024年第2期149-152,共4页Journal of Medical Information

摘　　要：目的观察胃黏膜保护剂联合质子泵抑制剂治疗消化性溃疡伴出血的临床效果。方法选取2019年5月-2022年5月在我院诊治的60例消化性溃疡伴出血患者为研究对象,采用随机数字表法分为对照组(n=30)和观察组(n=30),对照组采用质子泵抑制剂治疗,观察组在对照组基础上联合胃黏膜保护剂。比较两组临床疗效、止血时间、溃疡愈合时间、腹痛消失时间、临床症状评分(腹痛、腹胀、反酸、嗳气)、炎症因子水平[C反应蛋白(CRP)、白细胞介素-6(IL-6)]以及不良反应发生率。结果观察组治疗总有效率为93.33%,高于对照组的80.00%(P<0.05);观察组止血时间、溃疡愈合时间、腹痛消失时间均短于对照组(P<0.05);观察组腹痛、腹胀、反酸、嗳气评分均低于对照组(P<0.05);两组治疗后CRP、IL-6水平均低于治疗前,且观察组低于对照组(P<0.05);观察组不良反应发生率(6.67%)低于对照组(16.67%)(P<0.05)。结论消化性溃疡伴出血采用胃黏膜保护剂与质子泵抑制剂联合治疗可提高总有效率,缩短临床症状消失时间,减少中医证候,降低炎性因子水平,且可减少不良反应,是一种安全、有效的治疗方案,值得临床应用。Objective To observe the clinical efficacy of gastric mucosal protective agent combined with hydrogen pump inhibitors in the treatment of peptic ulcer bleeding.Methods From May 2019 to May 2022,60 patients with peptic ulcer bleeding diagnosed and treated in our hospital were selected as the research objects.They were divided into control group(n=30)and observation group(n=30)by random number table method.The control group was treated with hydrogen pump inhibitors,and the observation group was combined with gastric mucosal protective agent on the basis of the control group.The clinical efficacy,hemostasis time,ulcer healing time,abdominal pain disappearance time,clinical symptom scores(abdominal pain,abdominal distension,acid reflux,belching),inflammatory factor levels[C-reactive protein(CRP),interleukin-6(IL-6)]and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%,which was higher than 80.00%in the control group(P<0.05).The hemostasis time,ulcer healing time and abdominal pain disappearance time in the observation group were shorter than those in the control group(P<0.05).The scores of abdominal pain,abdominal distension,acid reflux and belching in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of CRP and IL-6 in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).The incidence of adverse reactions in the observation group(6.67%)was lower than that in the control group(16.67%)(P<0.05).Conclusion The combined treatment of gastric mucosal protective agent and Proton-pump inhibitor can increase the total effective rate,shorten the time of clinical symptoms disappearing,reduce the TCM syndrome and inflammatory factors in peptic ulcer with bleeding,and can reduce adverse reactions,is a safe and effective treatment,worthy of clinical application.

关 键 词：胃黏膜保护剂 质子泵抑制剂 消化性溃疡 出血 

分 类 号：R969.4[医药卫生—药理学]