血清降钙素原联合超敏C反应蛋白对大叶性肺炎患儿预后的预测价值  

Prognostic Value of Serum Procalcitonin Combined with Hypersensitive C Reactive Protein in Children with Lobar Pneumonia

作　　者：王耀邦[1] 沙宁[1] 张逸娴 WANG Yaobang;SHA Ning;ZHANG Yixian(Department of Pediatrics,Huai’an Second People's Hospital,Huai’an 223002,China;不详)

机构地区：[1]淮安市第二人民医院儿科,江苏淮安223002

出　　处：《中国医学创新》2024年第2期142-145,共4页Medical Innovation of China

摘　　要：目的:探讨降钙素原(PCT)联合超敏C反应蛋白(hs-CRP)对大叶性肺炎患儿预后的预测价值。方法:选择2019年1月—2022年1月于淮安市第二人民医院儿科病房住院的103例大叶性肺炎患儿为研究对象。检测所有患儿血清PCT、hs-CRP水平,根据患儿的预后情况分为治疗不佳组(n=10)与治愈组(n=93),收集患儿的临床资料,以多因素logistic回归分析大叶性肺炎的危险因素,制作受试者操作特征(ROC)曲线,以曲线下面积(AUC)评估血清PCT、hs-CRP对大叶性肺炎预后的预测价值。结果:两组患儿年龄、性别、身高、体重、白细胞计数对比,差异均无统计学意义(P>0.05);治疗不佳组hs-CRP、PCT水平均明显高于治愈组(P<0.05)。多因素logistic回归分析显示,血清PCT、hs-CRP均为大叶性肺炎治疗不佳的危险因素(P<0.05)。血清PCT、hs-CRP单一及联合预测大叶性肺炎治疗不佳的AUC分别为0.805、0.810、0.921,联合预测AUC高于单一预测(P<0.05)。结论:大叶性肺炎患儿血清PCT、hs-CRP水平明显升高,与大叶性肺炎治疗不佳密切相关,且两者在预测大叶性肺炎预后中具有重要价值,PCT、hs-CRP联合预测大叶性肺炎治疗不佳价值更高。Objective:To investigate the prognostic value of procalcitonin(PCT)combined with hypersensitive C reactive protein(hs-CRP)in children with lobular pneumonia.Method:A total of 103 children with lobular pneumonia who were hospitalized in the Pediatric Ward of Huai’an Second People's Hospital from January 2019 to January 2022 were selected as the study objects.Serum PCT and hs-CRP levels of all children were detected,and the children were divided into poor treatment group(n=10)and cured group(n=93)according to the prognosis.Clinical data of the children were collected,and the risk factors of lobed pneumonia were analyzed by multivariate logistic regression,and receiver operating characteristic(ROC)curves were developed,area under the curve(AUC)was used to evaluate the predictive value of serum PCT and hs-CRP in lobar pneumonia.Result:There were no significant differences in age,sex,height,weight and white blood cell count between the two groups(P>0.05);the levels of hs-CRP and PCT in poor treatment group were higher than those in cured group(P<0.05).Multivariate logistic regression analysis showed that serum PCT and hs-CRP were risk factors for poor treatment of lobular pneumonia(P<0.05).The AUC of single and combined prediction of serum PCT and hs-CRP for poor treatment of lobar pneumonia were 0.805,0.810 and 0.921,respectively,and the AUC of combined prediction was higher than those of single prediction(P<0.05).Conclusion:The levels of serum PCT and hs-CRP in children with lobar pneumonia are abnormal,and the levels of blood PCT and hs-CRP are closely related to the poor treatment of lobar pneumonia,and the two are of great value in predicting the poor treatment of lobar pneumonia,and the combined prediction value is higher in predicting the poor treatment of lobar pneumonia.

关 键 词：血清降钙素原 超敏C反应蛋白 大叶性肺炎 治疗不佳 

分 类 号：R725.6[医药卫生—儿科]