青海省104名成人大骨节病患者血清IL-1β检测结果分析  

Analysis of IL-1β detection in serum of 104 adult patients with Kashin-Beck disease in Qinghai Province

作　　者：周昕[1] 曹有平 王明君 孟献亚[1] 李亚楠[1] 蒲光兰[1] 喇翠玲[1] 胡兰盛[1] 沈洪婷[1] 李强[1] ZHOU Xin;CAO Youping;WANG Mingjun;MENG Xianya;LI Yanan;PU Guanglan;LA Cuiling;HU Lansheng;SHEN Hongting;LI Qiang(Qinghai Institute for Endemic Disease Control and Prevention,Xining,Oinghai 811602,China;不详)

机构地区：[1]青海省地方病预防控制所,青海西宁811602 [2]城中区南川东路社区卫生服务中心

出　　处：《中国地方病防治》2023年第5期368-369,共2页Chinese Journal of Control of Endemic Diseases

基　　金：2022年度青海省卫生健康委员会指导性计划课题(2022-wjzdx-33)。

摘　　要：目的了解青海成人大骨节病患者血清中炎性因子白细胞介素-1β的表达情况。方法将20岁以上目标人群作为调查对象,根据《大骨节病诊断标准》(WS/T 207—2010),将调查对象分为病例组和病区内、外对照组。采用酶联免疫吸附法检测调查对象血清中IL-1β含量,应用SPSS 17.0软件进行数据统计分析。结果三组间年龄比较差异无统计学意义(F=2.236,P=0.109)。三组间血清IL-1β含量比较差异有统计学意义(F=61.04,P=0.001),大骨节病例组患者IL-1β含量显著升高。结论青海高原成人大骨节病患者体内炎性因子含量升高,存在炎性改变。Objective To investigate the expression of interleukin-1β in serum of adult patients with Kashin-Beck disease(KBD)in Qinghai.Methods The target population over 20 years old was selected as the investigation objects.According to the“Diagnostic Criteria for Kashin-Beck Disease(WS/T 207—2010)”,the investigation objects were divided into case group and internal and external control groups.The content of IL-Iβ in serum was detected by enzyme-linked immunosorbent assay,and the data were statistically analyzed by SPSS 17.0 software.Results There was no significant difference in age among the three groups(F=2.236,P=0.109).There was significant difference in serum IL-1β content among the three groups(F=61.04,P=0.001).Conclusion The content of IL-1β in adult patients with KBD in Qinghai Plateau increased and inflammatory changes were observed.

关 键 词：成人大骨节病 白细胞介素-1Β 青海省 

分 类 号：R681.1[医药卫生—骨科学]