新疆帕米尔高原塔吉克族血脂异常患病率及相关因素分析  

Analysis of the prevalence of dyslipidemia and correlative factors in Tajik population in Pamir Plateau of Xinjiang

作　　者：金梦龙 马吾苏木·马木特 合巴丽·沙帕尔买买提 李建新[4] 曹杰[4] 李华垠 孟凡华 赵倩[5] 姬虹宇 贾林·阿布扎力汗 阿布都哈力克·艾盖西 鲁向锋[4] 付真彦[1] Jin Menglong;Mamute Mawusumu;Shapaermaimaiti Hebali;Li Jianxin;Cao Jie;Li Huayin;Meng Fanhua;Zhao Qian;Ji Hongyu;Abuzhalihan Jialin;Aigaixi Abuduhalike;Lu Xiangfeng;Fu Zhenyan(Department of Cardiology and State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;Department of Urology,First People's Hospital of Kashgar District,Kashgar 844099,China;Disease Control and Prevention Center of Tashkurgan Tajik Autonomous County,Kashgar 845250,China;Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China;Department of Cardiology,First Afiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;Department of Cardiology of Affiliated Hospital of Jining Medical University,Jining 272007,China;Health Commission of Tashkurgan Tajik Autonomous County,Kashgar 845250,China)

机构地区：[1]新疆医科大学第一附属医院心脏中心,新疆医科大学省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐830011 [2]喀什地区第一人民医院泌尿外科,喀什844099 [3]塔什库尔干塔吉克自治县疾病预防控制中心,喀什845250 [4]北京协和医学院国家心血管病中心中国医学科学院阜外医院流行病研究部,北京100037 [5]新疆医科大学第一附属医院心脏中心,乌鲁木齐830011 [6]济宁医学院附属医院心血管内科,济宁272007 [7]塔什库尔干塔吉克自治县卫生健康委员会,喀什845250

出　　处：《中华心血管病杂志》2023年第12期1240-1246,共7页Chinese Journal of Cardiology

基　　金：国家重点研发计划(2021YFC2500600,2021YFC2500605);自治区科技支疆项目计划(2020E0278);省部共建中亚高发病成因与防治国家重点实验室开放课题资助项目(SKL-HIDCA-2022-XXG3);国家创新研究群体培育项目(XYD2021C002);国家自然科学基金(81970380)。

摘　　要：目的了解新疆帕米尔高原塔吉克族血脂水平及血脂异常流行情况,探索血脂异常的相关因素。方法本研究为横断面研究。于2021年5至10月在新疆塔什库尔干塔吉克自治县采用多阶段整群随机抽样调查了5635名18岁以上塔吉克族,收集问卷调查(一般信息、疾病史、个人史等)、体格检查(身高、体重、腰围、血压等)和血液标本检测数据[总胆固醇(TC),甘油三酯(TG),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C)等],分析塔吉克族血脂异常患病情况及相关因素。结果塔吉克族研究对象年龄(41.9±15.0)岁,男性2726人(48.4%)。TC、LDL-C、TG水平边缘升高患病率分别为17.2%、14.7%、8.9%。高TC血症、高LDL-C血症、高TG血症、低HDL-C血症患病率分别为4.1%、4.9%、9.4%、32.4%,血脂异常患病率为37.0%。男性、更高的文化程度、更大的体重指数和腰围、生活在城镇、吸烟是血脂异常的正相关因素。结论新疆帕米尔高原塔吉克族血脂异常患病情况以较低的高TC、高LDL-C和高TG血症患病率和较高的低HDL-C血症患病率为主要特点。较低的超重和肥胖率可能是塔吉克族血脂异常患病率较低的原因之一。Objective To investigate the prevalence of dyslipidemia and the level of blood lipids among Tajik people in Pamir Plateau,Xinjiang,and explore the related factors of dyslipidemia.Methods It is a retrospective cross-sectional study.A multi-stage cluster random sampling survey was conducted among 5635 Tajiks over 18 years old in Tashkorgan Tajik Autonomous County,Xinjiang Province from May to October 2021.Data were collected through questionnaire survey(general information,medical history,and personal history),physical examination(height,weight,waist,and blood pressure)and blood test(total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),and high-density cholesterol(HDL-C))to analyze the dyslipidemia and its risk factors among Tajiks.Results The age of Tajik participants was(41.9±15.0)years,including 2726 males(48.4%).The prevalence of borderline high TC,high LDL-C and high TG levels were 17.2%,14.7%and 8.9%,respectively.The prevalence of high TC,high LDL-C,high TG and low HDL-C were 4.1%,4.9%,9.4%and 32.4%,respectively,and the prevalence of dyslipidemia was 37.0%.There is a positive correlation between male,higher education level,higher body mass index(BMI)value,waist circumference,living in town,smoking and dyslipidemia.Conclusions The low prevalence of high TC,high LDL-C,high TG and high prevalence of low HDL-C was a major characteristic of Tajik people in Pamir Plateau of Xinjiang.The lower rates of overweight and obesity may be one of the reasons for the lower prevalence of dyslipidemia among Tajik.

关 键 词：血脂异常 塔吉克族 横断面研究 帕米尔高原 

分 类 号：R589.2[医药卫生—内分泌]