补气温阳定狂汤治疗躁狂症患者临床疗效及对血清炎症因子水平的影响  

Clinical efficacy of the Buqi Wenyang Dingkuang decoction on mania patients and its effect on serum inflammatory factor levels

作　　者：卢林生 刘赟[2] 李一兰 陈健华[2] 肖攀攀[2] LU Linsheng

机构地区：[1]广州医科大学附属脑科医院江村分院,广东广州510000 [2]广州医科大学附属脑科医院,广东广州510370

出　　处：《中医临床研究》2023年第35期41-45,共5页Clinical Journal Of Chinese Medicine

基　　金：广东省中医药局科研项目(20211305):补气温阳定狂汤治疗虚阳上浮型躁狂症的疗效观察。

摘　　要：目的:探讨补气温阳定狂汤治疗躁狂症患者临床疗效及对血清炎症因子水平影响。方法:选择广州医科大学附属脑科医院于2021年3月-2022年6月收治的躁狂症患者82例,按随机分为研究组与对照组,各41例。对照组患者口服丙戊酸钠缓释片和富马酸喹硫平片治疗,研究组在丙戊酸钠缓释片和富马酸喹硫平片基础上口服补气温阳定狂汤。两组连续治疗4周。比较两组治疗4周临床疗效,治疗前、治疗2周与治疗4周贝克-拉范森躁狂量表(Bech-Rafaelsdn Mania Rating Scale,BRMS),临床总体印象量表(Clinical Global Impression,CGI)评分变化,治疗前与治疗4周的炎症因子水平和中医症状积分变化,及不良反应情况。结果:研究组治疗后躁狂症患者总有效率高于对照组(P <0.05)。两组治疗2周和治疗4周的BRMS评分较治疗前降低(P <0.05);研究组治疗2周和治疗4周的BRMS评分低于对照组(P <0.05)。两组治疗2周和治疗4周的CGI评分较治疗前降低(P <0.05);研究组治疗2周和治疗4周的CGI评分低于对照组(P <0.05)。两组治疗4周的血清白细胞介素(Interleukin,IL)-1β,IL-10和肿瘤坏死因子(Tumor Necrosis Factor,TNF)-α水平较治疗前降低,而血清IL-10水平较治疗前增加(P <0.05);研究组治疗4周时血清IL-1β和TNF-α水平低于对照组,而血清IL-10水平高于对照组(P <0.05)。两组治疗4周时狂躁不安、渴不欲饮和肢冷积分低于治疗前(P <0.05);研究组治疗4周躁狂症患者狂躁不安、渴不欲饮和肢冷积分低于对照组(P <0.05)。研究组躁狂症患者不良反应低于对照组(P <0.05)。结论:补气温阳定狂汤治疗躁狂症患者临床疗效显著,可减轻患者躁狂症状和病情,及减轻患者炎症反应。Objective:To investigate the clinical efficacy of the Buqi Wenyang Dingkuang decoction(补气温阳定狂汤)on patients with mania and its effect on serum inflammatory factor levels.Methods:A total of 82 patients with mania who were admitted to our hospital from March 2021 to June 2022 were selected and randomly divided into the study group and the control group,with 41O cases in each.The control group were treated with Sodium Valproate Sustained-Release Tablets and Quetiapine Tablets orally,while the study group was treated with the Buqi Wenyang Dingkuang decoction on the basis of the control group.The two groups were treated continuously for 4 weeks.The clinical efficacy in the two groups after 4 weeks of treatment was compared.Before treatment,after 2 weeks of treatment and 4 weeks after treatment,Bech-rafaelsdn mania rating scale(BRMS),Clinical global impression scale(CGI)score were compared.Changes in inflammatory factor levels and TCM symptoms before treatment and 4 weeks after treatment,and adverse reactions were compared.Results:After treatment,the total efficiency in the study group was higher than that in the control group(P<0.05).After 2 and 4 weeks of treatment,the BRMS score in the two groups was lower than that before treatment(P<0.05).After 2 weeks and 4 weeks of treatment,the BRMS score in the study group was lower than that in the control group.After 2 and 4 weeks of treatment,the CGI score in the two groups was lower than that before treatment(P<0.05).After 2 weeks and 4 weeks of treatment,the CGI score in the study group was lower than that in the control group.After 4 weeks of treatment,the levels of IL-1βand TNF-αdecreased,while the level of serum IL-10 increased in both groups.After 4 weeks of treatment,the levels of serum IL-1βand TNF-αin the study group were lower than those in the control group,while the level of serum IL-10 in the study group was higher than that in the control group.After 4 weeks of treatment,the scores of manic restlessness,thirst and cold limbs in both groups wer

关 键 词：补气温阳定狂汤 躁狂症 炎症因子 

分 类 号：R277.7[医药卫生—中医学]