米力农治疗急性心功能不全合并呼吸衰竭及肾功能不全的临床疗效  

Clinical effect of Milrinone in the treatment of acute cardiac insufficiency complicated with respiratory failure and renal insufficiency

作　　者：杜斌 肖国龙 邓鹏 刘林松 谢良冬 DU Bin;XIAO Guolong;DENG Peng;LIU Linsong;XIE Liangdong(Department of Emergency,Fifth People's Hospital of Ganzhou City,Ganzhou,Jiangxi,341000,China)

机构地区：[1]赣州市第五人民医院急诊科,江西赣州341000

出　　处：《当代医学》2023年第25期1-5,共5页Contemporary Medicine

摘　　要：目的探讨米力农与去乙酰毛花苷治疗急性心功能不全(ACI)合并呼吸衰竭及肾功能不全的临床疗效。方法选取2015年3月至2020年8月赣州市第五人民医院收治的120例明确诊断为ACI合并呼吸衰竭及肾功能不全患者作为研究对象,根据患者入院时治疗药物不同分为A组、B组与C组,每组40例。A组行常规药物治疗,B组在A组基础上静脉注射去乙酰毛花苷治疗,C组在A组基础上给予米力农静脉注射治疗,比较3组临床疗效、治疗前后心功能指标[左心室射血分数(LVEF)、左心室舒张末内径(LVEDD)、短轴缩短率(FS)]、拔管率、脱机率、不同时间点呼吸功能指标[呼吸机支持压力(PS)及呼吸机氧浓度变化]、治疗前后肾小球滤过率(eGFR)。结果3组治疗总有效率比较差异有统计学意义(P<0.05);C组总有效率明显高于A组、B组,且B组明显高于A组,差异有统计学意义(P<0.05)。治疗后,3组LVEDD明显短于治疗前,LVEF、FS明显高于治疗前,且C组LVEDD明显短于A组、B组,LVEF、FS均明显高于A组、B组,B组LVEDD明显短于A组,LVEF、FS均明显高于A组,差异有统计学意义(P<0.05)。3组拔管率比较差异无统计学意义。3组脱机率比较差异有统计学意义(P<0.05),C组脱机率明显高于A组,差异有统计学意义(P<0.05);其他各组两两比较差异无统计学意义。3组呼吸机氧浓度、PS随治疗时间延长,呈逐渐降低趋势,且C组低于A组、B组,B组低于A组,差异有统计学意义(P<0.05)。治疗后,3组eGFR均高于治疗前,且C组明显高于A组、B组,B组明显高于A组,差异有统计学意义(P<0.05)。3组不良反应发生率比较差异有统计学意义(P<0.05)。C组不良反应发生率明显低于A组,差异有统计学意义(P<0.05),其他各组两两比较差异无统计学意义。结论米力农治疗ACI合并呼吸衰竭及肾功能临床疗效显著,可明显提高患者心功能和肾功能,有效改善呼吸困难等症状,提高脱机率,且临床不�Objective To investigate the clinical efficacy of Milrinone and deacetyllanoside in the treatment of acute cardiac insufficiency(ACI)complicated with respiratory failure and renal insufficiency.Methods A total of 120 patients with ACI combined with respiratory failure and renal insufficiency admitted to Fifth People's Hospital of Ganzhou City from March 2015 to August 2020 were selected as the study subjects,and they were divided into the group A,group B and group C according to different therapeutic drugs at admission,with 40 cases in each group.Group A re-ceived conventional drug treatment,group B received intravenous deacetyllanoside treatment on the basis of group A,group C received intravenous milrinone treatment on the basis of group A.The clinical efficacy,cardiac function indexes(left ventricular ejection fraction[LVEF],left ventricular end-diastolic diameter[LVEDD],fractional shortenin[FS])before and after treatment,extubation rate,extubation probability,respiratory function in-dexes(pressure support[PS]and ventilator oxygen concentration changes)at different time points and glomerular filtration rate(eGFR)before and af-ter treatment were compared among the three groups.Results There was significant difference in the total effective rate among the three groups(P<0.05);the total effective rate in the group C was significantly higher than that in the groups A and B,and the group B was significantly higher than the group A,and the differences were statistically significant(P<0.05).After treatment,the LVEDD among the three groups were significantly short-er than before treatment,LVEF and FS were significantly higher than before treatment,LVEDD in the group C was significantly shorter than that in the groups A and group B,LVEF and FS were significantly higher than those in the groups A and group B,LVEDD in the group B was significantly shorter than that in the group A,LVEF and FS were significantly higher than those in the group A,the differences were statistically significant(P<0.05).There was no significant

关 键 词：米力农 去乙酰毛花苷 急性心功能不全 呼吸衰竭 肾功能不全 

分 类 号：R563.8[医药卫生—呼吸系统]