黄体酮联合加味寿胎丸治疗肾虚型早期先兆流产的临床疗效  

Clinical effect of progesterone combined with modified Jiawei Shoutai pill on early threatened abortion with kidney deficiency

作　　者：胡永平 HU Yongping(Department of Obstetrics,Pingyi County Hospital of Traditional Chinese Medicine,Linyi,Shandong,273300,China)

机构地区：[1]平邑县中医医院产科,山东临沂273300

出　　处：《当代医学》2023年第25期24-28,共5页Contemporary Medicine

摘　　要：目的探究黄体酮联合加味寿胎丸治疗肾虚型早期先兆流产(TA)的临床疗效。方法选取2020年2月至2021年2月平邑县中医医院收治的62例肾虚型早期TA患者作为研究对象,随机分为观察组与对照组,每组31例。对照组给予黄体酮治疗,观察组在对照组治疗基础上给予加味寿胎丸治疗,比较两组治疗前后性激素[孕酮(P)、β-人绒毛膜促性腺激素(β-hCG)、雌二醇(E2)]水平、血清炎症因子[γ-干扰素(INF-γ)、白细胞介素-4(IL-4)、白细胞介素-2(IL-2)]水平、中医证候积分和临床疗效、不良反应发生情况。结果治疗前,两组P、β-hCG、E2水平比较差异无统计学意义;治疗14 d后,两组P、β-hCG、E2水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组INF-γ、IL-4、IL-2水平比较差异无统计学意义;治疗14 d后,两组INF-γ、IL-2水平均低于治疗前,IL-4水平均高于治疗前,且观察组INF-γ、IL-2水平均低于对照组,IL-4水平高于对照组,差异有统计学意义(P<0.05)。治疗前,两组下腹疼痛与坠胀、腰膝酸软、阴道流血量评分比较差异无统计学意义;治疗14d后,两组下腹疼痛与坠胀、腰膝酸软、阴道流血量评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论黄体酮联合加味寿胎丸治疗TA疗效确切,可纠正炎症因子水平,促进性激素分泌,缓解临床症状,安全性高,值得临床推广应用。Objective To explore the clinical effect of progesterone combined with modified Jiawei Shoutai pill on early threatened abortion(TA)with kidney deficiency.Methods A total of 62 patients with early TA with kidney deficiency treated in Pingyi County Hospital of Traditional Chinese Medicine from February 2020 to February 2021 were selected as the study subjects,and they were randomly divided into the observation group and the control group,with 31 cases in each group.The control group was treated with progesterone,and the observation group was treated with modified Jiawei Shoutai pill on the basis of the control group,the levels of sex hormones(progesterone[P],β-human chorionic gonadotropin[β-hCG],estradiol[E2]),serum inflammatory factors(interferon-γ[INF-γ],interleukin-4[IL-4],interleukin-2[IL-2]),Traditional Chinese Medicine syn-drome scores before and after treatment,clinical efficacy and incidence of adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in P,β-hCG and E2 levels between the two groups;after 14 d of treatment,the levels of P,β-hCG and E2 of the two groups were higher than before treatment,and the observation group was higher than control group,the differences were statistically signifi-cant(P<0.05).Before treatment,there were no significant differences in INF-γ,IL-4 and IL-2 levels between the two groups;after 14 d of treatment,the levels of INF-γand IL-2 of the two groups were lower than before treatment,and the levels of IL-4 were higher than before treatment,and the lev-els of INF-γand IL-2 in the observation group were lower than control group,and the level of IL-4 was higher than that in control group,the differenc-es were statistically significant(P<0.05).Before treatment,there were no significant differences in the scores of lower abdominal pain,distension,waist and knee tenderness and vaginal bleeding between the two groups;after 14 d of treatment,the scores of lower abdominal pain and distention,waist and knee tender

关 键 词：黄体酮 加味寿胎丸 肾虚型 早期先兆流产 不良反应 

分 类 号：R271.4[医药卫生—中医妇科学]