不同时机抗菌药物干预对剖宫产产妇术后盆腔感染风险的影响  

Effect of antibacterial intervention at different timing on the risk of pelvic infection after cesarean section

作　　者：应小芳 马玲 祝丽霞 YING xiaofang;MA Ling;ZHU Lixia(Department of Obstetrics and Gynecology,First Affiliated Hospital of Jiangxi Medical College,Shangrao,Jiangxi,334000,China)

机构地区：[1]江西医学高等专科学校第一附属医院妇产科,江西上饶334000

出　　处：《当代医学》2023年第25期60-63,共4页Contemporary Medicine

摘　　要：目的探究不同时机抗菌药物干预对剖宫产产妇术后盆腔感染风险的影响。方法选取2019年7月至2021年7月于江西医学高等专科学校第一附属医院行剖宫产的60例产妇作为研究对象,按照给予抗菌药物时机不同分为A组、B组、C组,每组20例。A组术前2h给予抗菌药物静脉滴注,B组术前30min给予抗菌药物静脉滴注,C组术后给予抗菌药物静脉滴注。比较3组围手术期指标(手术时间、术中出血量、住院时间、体温恢复时间、最高体温)、炎症因子[WBC、C-反应蛋白(CRP)、γ-干扰素(INF-γ)]水平、新生儿相关指标[经皮胆红素测定(TcB)值、体质量及1minApgar评分]及产妇术后感染情况。结果B组住院时间、体温恢复时间均短于A组、C组,最高体温低于A组、C组,差异有统计学意义(P<0.05),A组与C组比较差异无统计学意义;3组手术时间、术中出血量比较差异无统计学意义。术后,3组WBC、CRP、INF-γ水平均高于术前,且B组WBC、CRP、INF-γ均低于A组、C组,差异有统计学意义(P<0.05),A组与C组比较差异无统计学意义。3组TcB值、体质量及1 minApgar评分比较差异无统计学意义。B组术后感染率(5.00%)低于A组(40.00%)、C组(40.00%),差异有统计学意义(P<0.05),A组与C组比较差异无统计学意义。结论剖宫产术前30min给予抗菌药物滴注,可有效缩短剖宫产术后产妇恢复时间,降低术后炎症因子水平及感染率,且安全性较高,值得临床推广应用。Objective To explore the effect of antimicrobial intervention at different times on the risk of pelvic infection after cesarean section.Methods 60 parturients who underwent cesarean section in the First Affiliated Hospital of Jiangxi Medical College from July 2019 to July 2021 were selected as the research subjects,and they were divided into the group A,the group B and the group C according to the timie of giving antibacte-rial drugs,with 20 cases in each group.The Group A was given intravenous antibiotics 2 h before surgery,group B was given intravenous antibiotics 30 min before surgery,and group C was given intravenous antibiotics after surgery.The perioperative indicators(operation time,intraoperative blood loss,hospitalization time,body temperature recovery time,maximum body temperature),levels of inflammatory factors(WBC,C-reactive protein[CRP],γ-interferon[INF-γ]),neonatal related indicators[transcutaneous bilirubinometer(TcB)value,body mass and 1 min Apgar score]and mater-nal infection after operation were compared among the three groups.Results The hospitalization time and body temperature recovery time in the group B were shorter than those in the group A and group C,and the highest body temperature was lower than that in the group A and group C,and the differences were statistically significant(P<0.05),while there was no statistically significant difference between group A and group C;there was no significant difference in operation time and intraoperative blood loss among the three groups.After operation,the WBC,levels of CRP and INF-γamong the three groups were higher than those before operation,and the WBC,CRP and INF-γin the group B were lower than those in the groups A and C,and the differences were statistically significant(P<0.05),while there was no statistically significant difference between the group A and group C.There was no significant difference in TcB value,body weight and 1 min Apgar score among the three groups.The postoperative infection rate in the group B(5.00%)was lower than tha

关 键 词：不同时机 抗菌药 剖宫产 盆腔感染 

分 类 号：R714.62[医药卫生—妇产科学]