阿司匹林联合硫酸镁对妊娠期高血压疾病患者超氧化物歧化酶和内皮素-1水平的影响  

Effect of aspirin combined with magnesium sulfate on the levels of superoxide dismutase and endothelin-1 in patients with gestational hypertension

作　　者：李静 肖丽霞 王小改 LI Jing;XIAO Lixia;WANG Xiaogai(Department of Obstetrics,Feicheng People's Hospital,Tai'an,Shandong,271600,China)

机构地区：[1]肥城市人民医院产科,山东泰安271600

出　　处：《当代医学》2023年第25期64-66,共3页Contemporary Medicine

摘　　要：目的探讨阿司匹林联合硫酸镁治疗妊娠期高血压的效果及对患者内皮素-1(ET-1)、超氧化物歧化酶(SOD)的影响。方法选取2019年1月至2020年12月肥城市人民医院产科接诊的88例妊娠期高血压患者作为研究对象,按照随机数字表法分为对照组与观察组,每组44例。对照组在常规治疗基础上辅以硫酸镁治疗,观察组在常规治疗基础上联合阿司匹林与硫酸镁治疗,比较两组临床疗效、用药前及分娩前血压(舒张压、收缩压)、ET-1、SOD水平及不良妊娠结局。结果观察组治疗总有效率为95.45%,高于对照组的77.27%,差异有统计学意义(P<0.05);分娩前,观察组舒张压、收缩压、ET-1水平均低于对照组,SOD水平高于对照组,差异有统计学意义(P<0.05);观察组不良妊娠结局发生率为2.27%,低于对照组的18.18%,差异有统计学意义(P<0.05)。结论阿司匹林联合硫酸镁可有效控制妊娠期高血压患者的血压水平,降低血清ET-1水平,提高血清SOD水平,改善分娩结局,值得临床推广应用。Objective To explore the effects of aspirin combined with magnesium sulfate in the treatment of gestational hypertension and its ef-fect on endothelin-1(ET-1)and superoxide dismutase(SOD).Methods 88 patients with gestational hypertension who were admitted to the depart-ment of Obstetrics in Feicheng People's Hospital from January 2019 to December 2020 were selected as the study subjects,and they were divided in-to the control group and the observation group according to the random number table method,with 44 cases in each group.The control group was treated with magnesium sulfate on the basis of conventional treatment,and the observation group was treated with aspirin and magnesium sulfate on the basis of conventional treatment,the clinical efficacy,blood pressure(diastolic blood pressure,systolic blood pressure),ET-1,SOD levels before medication and delivery,adverse pregnancy outcomes were compared between the two groups.Results The total effective rate in the observation group was 95.45%,which was higher than 77.27%in the control group,and the difference was statistically significant(P<0.05);before delivery,the diastolic blood pressure,systolic blood pressure and level of ET-1 in the observation group were lower than those in the control group,the level of SOD was higher than that in the control group,and the differences w ere statistically significant(P<0.05).The incidence of adverse pregnancy out-comes in the observation group was 2.27%,which was lower than 18.18%in the control group,and the difference was statistically significant(P<0.05).Conclusion Aspirin combined with magnesium sulfate can effectively control blood pressure level of patients with gestational hypertension,reduce ET-1 level,improve SOD level,and improve the outcome of childbirth,which is worthy of clinical promotion and application.

关 键 词：产科 妊娠期高血压疾病 阿司匹林 硫酸镁 内皮素-1 超氧化物歧化酶 

分 类 号：R714.252[医药卫生—妇产科学]