阿法骨化醇冲击治疗对慢性肾衰竭长期血透患者继发性甲状旁腺功能亢进的疗效分析  

Analysis of the effect of alfacalcitol shock treatment on patients with chronic renal failure and long-term hemodialysis with secondary hyperparathyroidism

作　　者：麻艳艳 MA Yanyan(Department of Nephrology,Liaocheng Dongchangfu People's Hospital,Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市东昌府人民医院肾内科,山东聊城252000

出　　处：《当代医学》2023年第25期88-91,共4页Contemporary Medicine

摘　　要：目的探讨阿法骨化醇冲击治疗慢性肾衰竭(CRF)长期血液透析患者继发性甲状旁腺功能亢进患者的临床效果。方法选取2020年8月至2021年8月于聊城市东昌府人民医院接受治疗的60例CRF患者作为研究对象,随机分为观察组与对照组,每组30例。对照组予以常规治疗,观察组予以阿法骨化醇冲击治疗,比较两组治疗前后血钙(BC)、血磷(BP)、碱性磷酸酶(ALP)等实验室指标、不同时间点甲状旁腺激素(PTH)及并发症发生情况。结果治疗后,两组BC水平均高于治疗前,BP、ALP水平均低于治疗前,且观察组BC水平高于对照组,BP、ALP水平均低于对照组,差异有统计学意义(P<0.05)。两组PTH组间、时间比较差异有统计学意义(P<0.05),两组PTH交互比较差异无统计学意义。治疗前,两组PTH水平比较差异无统计学意义;治疗3、7、14 d,两组PTH水平均低于前一时间点,且观察组低于对照组,差异有统计学意义(P<0.05)。两组并发症发生率比较差异无统计学意义。结论阿法骨化醇冲击治疗CRF长期血液透析并发甲状旁腺功能亢进患者可有效控制BC、BP、ALP水平,通过降低PTH水平改善患者甲状旁腺功能,患者并发症发生率并未增加,值得临床推广应用。Objective To investigate the effect of alfacalcitol shock treatment on patients with chronic renal failure(CRF)and long-term hemodi-alysis with secondary hyperparathyroidism.Methods A total of 60 patients with CRF who received treatment in Liaocheng Dongchangfu People's Hospital from August 2020 to August 2021 were selected as the study subjects,and they were randomly divided into the observation group and the control group,with 30 cases in each group.The control group was given routine treatment,and the observation group was given alfacalcitol shock treatment.The laboratory indexes such as blood calcium(BC),blood phosphorus(BP),alkaline phosphatase(ALP)before and after treatment,para-thyroid hormone(PTH)at different time points and complications were compared between the two groups.Results After treatment,the levels of BC of the two groups were higher than before treatment,the levels of BP and ALP were lower than before treatment,and the level of BC in the observa-tion group was higher than that in the control group,the levels of BP and ALP were lower than those in the control group,the differences were statisti-cally significant(P<0.05).There were statistically significant differences in PTH between the two groups of group,time points(P<0.05),while there was no statistically significant difference in PTH between the two groups of interaction.Before treatment,there was no significant difference in PTH level between the two groups;after 3,7 and 14 days of treatment,the PTH level in both groups was lower than the previous time point,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in complication rate between the two groups.Conclusion Alfacalcitol shock treatment can effectively control the levels of BC,BP and ALP in pa-tients with long-term hemodialysis complicated by hyperparathyroidism of CRF,improve the parathyroidism of patients by reducing PTH level,and the risk of complications after treatment not increa

关 键 词：慢性肾衰竭 继发性甲状旁腺功能亢进 阿法骨化醇冲击治疗 

分 类 号：R581[医药卫生—内分泌] R692[医药卫生—内科学]