低分子肝素治疗小儿肾病综合征的效果及对患者尿蛋白与血浆白蛋白的影响  

The effect of low molecular weight heparin in the treatment of pediatric nephrotic syndrome and its impact on urinary protein and plasma albumin

作　　者：袁鑫 李杰 汪意 YUAN Xin;LI Jie;WANG Yi(Department of Pediatric,Shangrao Municipal Hospital,Shangrao,Jiangxi,334000,China)

机构地区：[1]上饶市立医院儿科,江西上饶334000

出　　处：《当代医学》2023年第25期156-159,共4页Contemporary Medicine

摘　　要：目的分析低分子肝素治疗小儿肾病综合征的效果及对患儿尿蛋白、血浆白蛋白的影响。方法选取2018年1月至2020年12月上饶市立医院收治的80例小儿肾病综合征患儿作为研究对象,随机分为常规组与研究组,每组40例。常规组给予常规药物治疗,研究组在常规组基础上联合低分子肝素治疗。比较两组肢体肿胀消失时间、面色苍白消失时间、治疗前后生化指标、临床疗效、并发症发生情况。结果研究组肢体肿胀消失时间、面色苍白消失时间均短于常规组,差异有统计学意义(P<0.05)。治疗前,两组尿蛋白、血肌酐、血浆白蛋白水平比较差异无统计学意义;治疗后,两组尿蛋白、血肌酐水平均低于治疗前,血浆白蛋白水平均高于治疗前,且研究组尿蛋白、血肌酐水平均低于常规组,血浆白蛋白水平高于常规组,差异有统计学意义(P<0.05)。研究组治疗总有效率为97.50%,高于常规组的75.00%,差异有统计学意义(P<0.05)。研究组并发症发生率低于常规组,差异有统计学意义(P<0.05)。结论常规药物联合低分子肝素治疗小儿肾病综合征疗效确切,可改善患儿水肿等症状,增强肾功能,缩短治疗时间,减少并发症的发生。Objective To analyze the effect of low molecular weight heparin in the treatment of pediatric nephrotic syndrome in children and its effect on urinary protein and plasma albumin.Methods A total of 80 children with pediatric nephrotic syndrome admitted to Shangrao Municipal Hospital from January 2018 to December 2020 were selected as research subjects,and they were randomly divided into the routine group and the re-search group,with 40 cases in each group.The routine group was treated with conventional drugs,and the research group was treated with low molec-ular weight heparin on the basis of the routine group,the disappearance time of limb swelling,disappearance time of pallor,biochemical index before and after treatment,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results The disappearance time of limb swelling and pallor in the research group were shorter than those in the routine group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in urinary protein,serum creatinine and plasma albumin levels between the two groups;after treatment,the levels of urinary protein and serum creatinine of the two groups were lower than before treatment,and the plasma albumin level was higher than before treatment,and the levels of urinary protein and serum creatinine in the research group were lower than those in the routine group,and the plasma albumin level was higher than that in the routine group,and the differences were statistically significant(P<0.05).The total effec-tive rate in the research group was 97.50%,which was higher than 75.00%in the routine group,and the difference was statistically significant(P<0.05).The complication rate in the research group was lower than that in the routine group,and the difference was statistically significant(P<0.05).Conclusion Conventional drugs combined with low molecular weight heparin are effective in the treatment of pediatric nephrotic syndrome in children,which can improv

关 键 词：肾病综合征 儿童 低分子肝素 尿蛋白 血浆白蛋白 

分 类 号：R726.9[医药卫生—儿科]