补肾活血膏联合隔药灸治疗肾虚血瘀型股骨头坏死  

Treatment of Kidney Deficiency and Blood Stasis Type Femoral Head Necrosis with Kidney Tonifying and Blood Activating Oral Paste Combined with Medicinal Moxibustion

作　　者：朱紫燕 阎晓霞[2] ZHU Ziyan;YAN Xiaoxia(The Third Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450008;Henan University of Chinese Medicine,Zhengzhou Henan China 450046)

机构地区：[1]河南中医药大学第三附属医院,河南郑州450008 [2]河南中医药大学,河南郑州450046

出　　处：《中医学报》2024年第1期210-215,共6页Acta Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(20-21ZY1026)。

摘　　要：目的:观察补肾活血膏联合隔药灸对肾虚血瘀型股骨头坏死(osteonecrosis of the femeral head,ONFH)患者疼痛、血脂、血液流变学的影响。方法:将95例ONFH患者随机分为研究组(n=48)与对照组(n=47)。对照组给予仙灵骨葆胶囊+阿仑膦酸钠片治疗,研究组给予补肾活血膏+隔药灸治疗。比较两组患者治疗前后的中医证候积分、视觉模拟量表(visual analogue scale,VAS)评分、髋关节Harris评分、血脂[总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、三酰甘油(triglyceride,TG)]、血液流变学[全血黏度、血浆黏度(plasma viscosity,PV)、红细胞聚集指数(red blood cell aggregation index,Arbe)、红细胞电泳时间(red blood cell electrophoresis time,EPT)、红细胞变形指数(red blood cell deformation index,TK)]及临床疗效。结果:(1)研究组有效率为91.67%,对照组为72.34%,两组比较,差异有统计学意义(P<0.05)。(2)治疗后,两组患者VAS评分均明显低于本组治疗前(P<0.05);研究组VAS评分为(1.92±0.71)分,低于同期对照组(P<0.05)。(3)治疗后,两组患者髋关节Harris评分均明显高于本组治疗前;研究组髋关节Harris评分为(88.33±8.11)分,高于同期对照组(P<0.05)。(4)治疗后,两组患者血清TC、TG、LDL-C均低于本组治疗前,研究组血清TC为(5.11±0.68)mmol·L^(-1)、TG为(1.43±0.42)mmol·L^(-1)、LDL-C为(2.33±0.71)mmol·L^(-1),均低于同期对照组(P<0.05)。(5)治疗后,两组患者全血黏度、PV、Arbe、EPT和TK均低于本组治疗前,研究组全血黏度(200 s^(-1))为(3.67±0.37)mPa·s^(-1)、全血黏度(30 s^(-1))为(4.88±0.58)mPa·s^(-1)、全血黏度(3 s^(-1))为(6.29±1.48)mPa·s^(-1)、PV为(1.43±0.62)mPa·s^(-1)、Arbe为(5.01±1.14)、EPT为(13.18±3.48)s、TK为(0.64±0.06),均低于同期对照组(P<0.05)。(6)两组均未见严重不良事件。结论:补肾活血膏联合�Objective:To observe the effects of Bushen Huoxue Oral Paste combined with herbal moxibustion on pain,blood lipids,and hemorheology in patients with osteonecrosis of the femoral head(ONFH)of kidney deficiency and blood stasis syndrome.Method:95 patients with ONFH were randomly divided into a study group(n=48)and a control group(n=47).The control group was treated with Xianlinggubao Capsules and Alendronate Sodium Tablets,while the study group was treated with Bushen Huoxue Oral Paste and herbal moxibustion.Compare the traditional Chinese medicine syndrome scores,visual analogue scale(VAS),hip Harris score,and blood lipids[total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),and triglycerides(TG)]between two groups of patients before and after treatment Hemorheology[whole blood viscosity,plasma viscosity(PV),red blood cell aggregation index(Arbe),red blood cell electrophoresis time(EPT),red blood cell deformation index(TK)]and clinical efficacy.Results:(1)The effective rate of the study group was 91.67%,while that of the control group was 72.34%.The difference between the two groups was statistically significant(P<0.05).(2)After treatment,the VAS scores of both groups of patients were significantly lower than before treatment in this group(P<0.05);The VAS score of the research group was(1.92±0.71),lower than that of the control group during the same period(P<0.05).(3)After treatment,the Harris scores of the hip joints in both groups of patients were significantly higher than before treatment in this group;The Harris score of the hip joint in the research group was(88.33±8.11)points,which was higher than that of the control group during the same period(P<0.05).(4)After treatment,the serum TC,TG,and LDL-C of both groups of patients were lower than before treatment.The serum TC of the study group was(5.11±0.68)mmol·L^(-1),TG was(1.43±0.42)mmol·L^(-1),and LDL-C was(2.33±0.71)mmol·L^(-1),all lower than that of the control group during the same period(P<0.0

关 键 词：股骨头坏死 肾虚血瘀证 补肾活血膏 隔药灸 疼痛 血液流变学 

分 类 号：R274.19[医药卫生—中医骨伤科学]