lncRNAH19早期表达对急性心肌梗死患者左心室重构的评价作用  

Early expressed circulating long noncoding RNA H19 is associated with left ventricular remodeling in patients with acute myocardial infarction

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作  者:李锦爽 徐子恒 高行娟 戚冉冉 丁浩 LI Jinshuang;XU Ziheng;GAO Xingjuan;QI Ranran;DING Hao(Department of Cardiology,Suqian Hospital Affiliated of Xuzhou Medical University,Suqian 223800,Jiangsu,China)

机构地区:[1]徐州医科大学附属宿迁医院心血管内科,宿迁223800

出  处:《医学研究与战创伤救治》2023年第10期1056-1060,共5页Journal of Medical Research & Combat Trauma Care

基  金:宿迁市自然科学基金(K202218);宿迁市中医药科技项目(HD202214);徐州医科大学附属医院科技发展基金(XYFM202325)。

摘  要:目的 探讨lncRNAH19早期表达对急性心肌梗死(AMI)患者左心室重构(LVR)的诊断价值。方法 连续入选60例AMI合并心功能不全(HF)患者,60例急性心肌梗死非HF患者以及60例非心脏病患者共180例。所有研究对象入组后行lncRNAH19、NT-proBNP、心肌酶谱、肌钙蛋白、超声心动图检查,6个月后复查超声心动图,评估lncRNAH19诊断AMI患者LVR效能。结果 与对照组相比,AMI患者血清lncRNAH19水平显著升高,72 h后lncRNAH19水平较前呈明显下降趋势(P<0.001);HF组LAD病变比例及Gensini score分值显著高于非HF组(P<0.05);多变量回归分析表明,心率是24 h lncRNAH19表达的独立预测因子(β=0.481,P=0.001);随访6个月,HF组患者LVEF水平显著低于非HF组,LVEDV、LVESV显著高于对照组,差异具有统计学意义(P<0.001);AMI患者中,24 h lncRNAH19表达水平与6个月LVRI呈正相关(r=0.578,P<0.001);lncRNAH19诊断AMI患者LVR的AUC为0.723,敏感性为79.4%,特异性为81.7%。结论 lncRNAH19可作为评估AMI患者早期LVR诊断工具,具有明确的临床实际应用价值和转化意义。Objective To exploring the diagnostic value of early expression of long noncoding RNA H19(lncRNAH19)in left ventricular remodeling(LVR)with acute myocardial infarction(AMI).Methods 60 patients with AMI and heart failure(HF),60 patients with AMI and 60 patients with non-heart disease were enrolledand determinedthe expression oflncRNAH19,NT-proBNP,myocardial enzymes,troponin and echocardiograph.Echocardiogram was re-examined 6 months later.Results The level of serum lncRNAH19 in AMI group was significantly higher,and the highest lncRNAH19 expression was found in HF group(P<0.001).After 72 hours,lncRNAH19 was significantly lower than that before.In patients undergoing PCI surgery,the proportion of LAD lesions and Gensini score in the HF group were significantly higher than that in non-HF group(P<0.05).Multivariate regressio-nanalysis indicated that the heart rate was an independent predictor of 24 hours lncRNAH19 expression(β=0.481,P=0.001).The left ventricular ejection fraction was decreased,while the left ventricular end systolic diameter and left ventricular end diastolic diameter were significantlyincreased after 6 months(P<0.05).24 h lncRNAH19 was positively correlated with LVRI at 6 months(r=0.578,P<0.001).The AUC of lncRNAH19 in diagnosing LVR in patients with AMI was 0.723,the sensitivity was 79.4%,and the specificity was 81.7%.Conclusion LncRNAH19 can be used as a diagnostic markerto evaluate early LVR in patients with AMI.

关 键 词:lncRNAH19 急性心肌梗死 心功能不全 左室重构 

分 类 号:R542.2[医药卫生—心血管疾病]

 

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