基于微环境生态观察生肌玉红膏对犬咬伤创面愈合的促进作用  

Observation on the promoting effect of Shengji Yuhong Ointment on wound healing of dog bites based on microenvironment ecology

作　　者：刘恒 李爱茹 高岩 李鹏[1] 宋亚杰 LIU Heng;LI Airu;GAO Yan;LI Peng;SONG Yajie(Fangshan Hospital,Beijing University of Chinese Medicine,Beijing 102400)

机构地区：[1]北京中医药大学房山医院急诊科,北京102400

出　　处：《现代中医临床》2023年第6期7-11,共5页Modern Chinese Clinical Medicine

基　　金：国家自然科学基金面上项目(No.82174388);北京中医药大学青年教师项目(No.2019-BUCMXJKY006)。

摘　　要：目的观察外用生肌玉红膏对犬咬伤Ⅲ级暴露创面愈合的促进作用。方法采用随机数字表法将入组患者随机分为治疗组20例、对照组20例。2组均以生理盐水、双氧水、碘伏常规换药,治疗组将生肌玉红膏涂于无菌纱条上,置于伤口中引流。对照组用无菌纱条置于伤口中引流。观察创面渗出液相关因子、创面愈合范围、创面愈合时间、自觉疼痛评分(VAS)。结果2组创面渗出液肿瘤坏死因子α(TNF-α)、白细胞介素1(IL-1)、白细胞介素6(IL-6)比较,治疗后较治疗前均降低,差异有统计学意义(P<0.05),治疗组较对照组降低更明显,差异有统计学意义(P<0.05);2组血小板衍生生长因子(PDGF)、转化生长因子α(TGF-α)比较,治疗后较治疗前均升高,差异有统计学意义(P<0.05),治疗组较对照组升高更明显,差异有统计学意义(P<0.05);2组血管内皮生长因子(VEGF)比较,治疗后较治疗前均升高,差异有统计学意义(P<0.05)。2组治疗后创面愈合范围较本组治疗前均降低,差异具有统计学意义(P<0.05)。治疗组创面愈合时间(15.61±6.47)d,对照组创面愈合时间(23.29±11.55)d,t=-2.033,P=0.042(P<0.05),差异具有统计学意义,治疗组愈合时间较对照组愈合时间短,差异具有统计学意义(P<0.05)。2组治疗后VAS评分均较本组治疗前降低,差异均有统计学意义(P<0.05),治疗组比对照组降低明显,差异有统计学意义(P<0.05)。结论生肌玉红膏可有效抑制犬咬伤Ⅲ级暴露创面微环境中的炎症因子,并提高相关生长因子活性,对创面愈合范围、愈合时间、疼痛指标等均有明显改善作用。Objective To observe the effect of Shengji Yuhong Ointment on promoting healing by regulating the micro-environment of grade Ⅲ exposed wounds of dog bites.Methods The enrolled patients were randomly divided into the treatment group(20 cases)and control group(20 cases)by the random number table method.Normal saline,hydrogen peroxide and iodoprene were used for routine dressing change in both groups.Shengji Yuhong Ointment was applied on sterile gauze in the treatment group and then placed onto the wounds for drainage.This was done with sterile gauze only in the control group.Wound exudation-related factors,healing range,time needed for healing and perceived pain score(VAS)were observed.Results Tumor necrosis factorα(TNF-α),interleukin-1(IL-1)and interleukin-6(IL-6)were compared between the two groups.After treatment,the levels were lower than before treatment,the difference was statistically significant(P<0.05).The reduction in the treatment group was greater than in the control group,the difference was statistically significant(P<0.05);Platelet-derived growth factor(PDGF)and transforming growth factorα(TGF-α)in both groups were higher after treatment than before,and the difference was statistically significant(P<0.05).The increase in the treatment group was greater than in the control group,and the difference was statistically significant(P<0.05).The vascular endothelial growth factor(VEGF)in both groups was higher after treatment than before,the difference was statistically significant(P<0.05).The wound healing range of the two groups after treatment was lower than that before,the difference was statistically significant(P<0.05).VAS score of both groups after treatment was lower than that before,the difference was statistically significant(P<0.05),the reduction in the treatment group was greater than in the control group,the difference was statistically significant(P<0.05).Conclusion Shengji Yuhong Ointment can effectively inhibit inflammatory factors in the wound microenvironment of grade Ⅲ exposed dog

关 键 词：犬咬伤 创面愈合 生肌玉红膏 中医药治疗 

分 类 号：R264[医药卫生—中医外科学]