p38-MAPK信号通路对骨骼肌再生的影响研究进展  

Research Progress on The Effect of p38 MAPK Signaling Pathway on Skeletal Muscle Regeneration

作　　者：党彩霞 朱袁婕 包雅婷 姚丽华 龚妍春 Dang Caixia;Zhu Yuanjie;Bao Yating;Yao Lihua;Gong Yanchun(School of Life Sciences,Jiangxi Science&Technology Normal University,Nanchang 330013,Jiangxi,P.R.China)

机构地区：[1]江西科技师范大学生命科学学院,江西南昌330013

出　　处：《江西科技师范大学学报》2023年第6期109-113,共5页Journal of Jiangxi Science & Technology Normal University

基　　金：国家自然科学基金(31960193);江西省“双千计划”科技创新高端人才项目(JXSQ2019201011);江西省教育厅科学技术研究项目(190596)。

摘　　要：丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路是真核细胞功能高度保守的调节因子,在细胞受到外界刺激引起的炎症反应、应激反应等生理病理过程中起着重要调控作用。P38丝裂原活化蛋白激酶(p38 mitogen-activated protein kinase,p38-MAPK)信号通路是MAPK通路的亚族之一,在细胞炎症、组织再生、免疫反应中起着重要的作用。p38-MAPK信号通路的激活在染色质重塑和关键肌生成转录因子的激活中起着关键作用,而肌卫星细胞的激活又影响着骨骼肌的再生修复。本文对p38-MAPK信号通路的调控机制及其介导骨骼肌再生的研究进展进行了综述,以期为深入了解相关机制提供理论依据,并为进一步治疗骨骼肌损伤提供一定的临床参考。Mitogen activated protein kinase(MAPK)signaling pathway is a highly conserved regulator of eukaryotic cell function,and plays an important role in regulating the inflammatory response,stress response and other physiological and pathological processes caused by external stimuli.The p38-MAPK pathway is one of the subfamilies of the MAPK pathway and plays an important role in cellular inflammation,tissue regeneration,and immune responses.The activation of p38-MAPK plays a key role in Chromatin remodeling and the activation of key myogenic transcription factors,while the activation of Myosatellite cell affects the regeneration and repair of skeletal muscle.This paper reviews the regulatory mechanisms of the p38-MAPK signaling pathway and its research progress in mediating skeletal muscle regeneration,aiming is to provide a theoretical basis for a deeper understanding of the related mechanisms and provide a certain clinical reference for further treatment of skeletal muscle injury.

关 键 词：P38-MAPK 信号通路 骨骼肌再生 肌卫星细胞 

分 类 号：G804.7[文化科学—运动人体科学]