不容忽视的儿童侵袭性真菌感染——流行病学现状与诊断和治疗策略  

Invasive fungal infections in children should not be underestimated:epidemiology,diagnosis and treatment strategies

作　　者：李琰冰 徐英春 张丽 Li Yanbing;Xu Yingchun;Zhang Li(Department of Laboratory Medicine,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;Graduate School,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院检验科,疑难重症及罕见病国家重点实验室,北京100730 [2]中国医学科学院北京协和医学院研究生院,北京100730 [3]侵袭性真菌病机制研究与精准诊断北京市重点实验室,北京100730

出　　处：《中华实用儿科临床杂志》2024年第1期2-6,共5页Chinese Journal of Applied Clinical Pediatrics

基　　金：中央高水平医院临床科研专项(2022-PUMCH-A-137);中国医学科学院医学与健康科技创新工程(2021-I2M-1-044)。

摘　　要：近年来随着免疫缺陷人群的不断扩大,真菌感染成为威胁人类健康的重要因素。同样,儿童中由于血液病、恶性肿瘤使用免疫抑制剂和广谱抗菌药物等而处于免疫抑制状态的患儿数量增多,使得儿童真菌感染总体死亡率仍较高,且显示出非白念珠菌和曲霉菌感染高发的趋势,真菌感染是导致危重症儿童死亡的重要原因之一。现介绍总结儿童侵袭性真菌感染的流行病学特征、诊断和治疗策略,以期使儿童真菌感染得到临床更多的重视,减少儿童侵袭性真菌感染的发生及改善预后。With the increasing number of people with immune deficiency in recent years,fungal infections become an important factor threatening human health.Likewise,the number of children who are immunosuppressed due to hematological diseases,malignancies,use of immunosuppressants and spectrum antibacterial drugs has increased,leading to a high mortality of fungal infections.Moreover,infections of the non-candida albicans and aspergillu are prevalent,serving as important causes for the death of critically ill children.Therefore,this review aims to introduce and summarize the epidemiological characteristics,diagnosis and treatment of pediatric invasive fungal infections,thus yielding the concern of pediatric invasive fungal infections,reducing the occurrence of pediatric fungal infections and improving the prognosis.

关 键 词：儿童 侵袭性真菌病 流行病学 诊断 治疗 

分 类 号：R725.1[医药卫生—儿科]