细胞焦亡在小儿外科疾病中的研究进展  

Research progress of pyroptosis in pediatric surgical diseases

作　　者：赵肖欢 金祝 Zhao Xiaohuan;Jin Zhu(Department of Pediatric Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China;Department of Pediatric Surgery,Guizhou Children′s Hospital,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院小儿外科,遵义563000 [2]贵州省儿童医院小儿外科,遵义563000

出　　处：《中华实用儿科临床杂志》2024年第1期77-80,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：贵州省科技计划项目(黔科合基础-ZK(2023)一般555)。

摘　　要：细胞焦亡是一种伴随着炎症反应的程序性细胞死亡方式, 主要通过炎症小体或脂多糖介导半胱天冬氨酸酶-1/4/5/11活化, 造成包括Gasdermin D在内的多种Gasdermin家族成员发生剪切, 细胞焦亡过程中伴随着大量促炎因子的释放, 从而引起各种疾病中的炎症反应。目前, 细胞焦亡在小儿外科疾病中的研究尚少。现总结细胞焦亡在小儿外科疾病(先天性巨结肠、胆道闭锁、新生儿坏死性小肠结肠炎、肿瘤等)中的研究进展, 发现部分小儿外科疾病的发生发展过程中均有细胞焦亡的参与, 对于细胞焦亡中具体发生机制和信号通路的研究将有助于这些小儿外科疾病的早期诊断和治疗。Pyroptosis is a kind of programmed cell death accompanied by inflammatory responses,which is mainly induced by the Caspase-1/4/5/11 activated mediated via inflammasomes or lipopolysaccharide.Pyroptosis causes the cleavage of various Gasdermin family members,including Gasdermin D,in which a large number of pro-inflammatory factors are released to cause inflammatory responses in various diseases.At present,pyroptosis has not been extensively analyzed in pediatric surgical diseases.This review summarizes the research progress of pyroptosis in pediatric surgical diseases like Hirschsprung′s disease,biliary atresia,neonatal necrotizing enterocolitis,and tumors.It is found that pyroptosis is involved in the occurrence and development of pediatric surgical diseases.The research on the specific mechanism of pyroptosis in pediatric surgical disease and involved signaling pathways contributes to the early diagnosis and treatment of some pediatric surgical diseases.

关 键 词：先天性巨结肠 胆道闭锁 新生儿坏死性小肠结肠炎 肿瘤 细胞焦亡 儿童 

分 类 号：R726[医药卫生—儿科]