外泌体与外泌体microRNAs在糖尿病周围神经病变发生发展中的研究进展  

Research progress on exosomes and exosomal microRNAs in the occurrence and development of diabetic peripheral neuropathy

作　　者：舒杨 李炜东 胡琼英[1] 熊大迁[1] Shu Yang;Li Weidong;Hu Qiongying;Xiong Daqian(Department of Laboratory,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;Department of medical technology,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学附属医院检验科,成都610072 [2]成都中医药大学医学技术学院,成都610075

出　　处：《中华预防医学杂志》2024年第1期141-147,共7页Chinese Journal of Preventive Medicine

基　　金：四川省科技厅重点研发项目(2020YFS0375)。

摘　　要：糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)是糖尿病神经损害的慢性并发症之一,也是导致慢性伤口及致残的主要原因。外泌体(exosomes)与外泌体microRNAs(miRNAs)与DPN密切相关,通过介导细胞间通讯,参与周围神经系统的信号转导及蛋白表达。但在高糖环境中,外泌体与外泌体miRNAs引起DPN发生发展的具体作用和机制尚不完全清楚,本文就高糖环境中外泌体与外泌体miRNAs在抑制轴突生长、促进炎症反应和诱导血管损伤方面促进DPN发生和发展进行阐述。Diabetic peripheral neuropathy(DPN)is one of the chronic complications of diabetic neuropathy,and also the main cause of chronic wounds and disability.Exosomes and exosomal-microRNAs(miRNAs)are closely related to DPN and participate in the signal transduction and protein expression of the peripheral nervous system by mediating intercellular communication.However,the specific role and mechanism of EVs and exosomal-miRNAs in the occurrence and development of DPN in high-glucose environments are not fully understood.This article reviews the promotion of EVs and exosomal-miRNAs in the occurrence and development of DPN in inhibiting axon growth,promoting inflammatory response,and inducing vascular injury in a high glucose environment.

关 键 词：糖尿病周围神经病变 外泌体 外泌体miRNAs 高糖环境 

分 类 号：R587.2[医药卫生—内分泌] R745[医药卫生—内科学]