骨髓增生异常综合征在斑马鱼中的研究进展  

Research progress of myelodysplastic syndrome in zebrafish

作　　者：易可欣 范尹尹 陈柳蓉 汪玉宝 朱文武 贾海波[1] 朱雄伟 Yi Kexin;Fan Yinyin;Chen Liurong;Wang Yubao;Zhu Wenwu;Jia Haibo;Zhu Xiongwei(College of Life Science and Technology,Huazhong University of Science and Technology,Hubei,Wuhan 430074,China;Wuhan Eagle Biotechnology Co,Ltd,Hubei,Wuhan 430200,China;School of Environmental Ecology and Biological Engineering,Wuhan Institute of Technology,Hubei,Wuhan,430205,China)

机构地区：[1]华中科技大学生命科学与技术学院,湖北武汉430074 [2]武汉鹰达生物科技有限公司,湖北武汉430200 [3]武汉工程大学环境生态与生物工程学院,湖北武汉430205

出　　处：《发育医学电子杂志》2024年第1期53-60,共8页Journal of Developmental Medicine (Electronic Version)

基　　金：国家自然科学基金(81770102);华中科技大学重点研发项目(2018YFA0801000)。

摘　　要：骨髓增生异常综合征(myelodysplastic syndrome,MDS)是一种常见的血液疾病,其发病率呈现逐年上升的趋势。斑马鱼作为一种生物医学研究的模式生物,广泛应用于各类疾病的研究中。本文关注了近年来血液疾病在斑马鱼中的研究,MDS在小鼠、大鼠和斑马鱼中的研究及动物模型的应用,揭示了斑马鱼模型在其中发挥的重要作用。Myelodysplastic syndrome(MDS)is a prevalent hematologic disorder,with its incidence steadily increasing.Zebrafish,as an established model organism in biomedical research,has been extensively utilized for investigating various diseases.This review specifically focuses on the research of blood diseases in zebrafish in recent years,the study of MDS in mice,rats and zebrafish and the application of animal models,showing the important role played by zebrafish models among them.

关 键 词：骨髓增生异常综合征 斑马鱼 动物模型 血液肿瘤疾病 药物筛选 

分 类 号：R551.3[医药卫生—血液循环系统疾病] R-332[医药卫生—内科学]