Oxidation of Difluorocarbene by Pyridine N-Oxide and Ensuing Access to Carbamoyl Fluorides  

作　　者：Hai-Jun Tang Xue-Min Shi Xiao-Yu Zhu Cheng-Qiang Wang Chao Feng 

机构地区：[1]Technical Institute of Fluorochemistry(TiF),Institute of Advanced Synthesis(iAs),State Key Laboratory of Material-Oriented Chemical Engineering,School of Chemistry and Moiecular Engineering,Nanjing TechUniversity,30 South Puzhu Road,Nanjing,Jiangsu211816,China

出　　处：《Chinese Journal of Chemistry》2023年第22期2981-2987,共7页中国化学（英文版）

基　　金：The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China(grant no.22271151)and the Distinguished Youth Foundation of Jiangsu Province.

摘　　要：A practical one-pot preparation of carbamoyl fluorides from easily obtained pyridine N-oxide,commercially available secondary amines and synthetically versatile difluorocarbene precursors(Ruppert-Prakash reagent or Chen's reagent)was developed herein,which dexterously resorted to the oxidation of difluorocarbene by external pyridine N-oxide to produce the toxic and gaseous fluorophosgene in situ.Notable features of this method include nice functionality tolerance,late-stage modification of drug molecules and the recoveryand recycle of quinoline.

关 键 词：Difluorocarbene Pyridine N-oxide Fluorophosgene Carbamoyl fluorides AMINES FLUORINE 

分 类 号：O62[理学—有机化学]