A Direct Route to Tetrahydropyridazine Derivatives via DMAP-Catalyzed [4+2] Annulation of Allenoates with Arylazosulfones  

作　　者：Xin Ji Ziyang Li Jinfeng Zhang Yicheng Zhang Ling-Guo Meng 

机构地区：[1]Key Laboratory of Green and Precise Synthetic Chemistry and Applications,Ministry of Education,School of Chemistry and Materials Science,Huaibei Normal University,Huaibei,Anhui 235000,China

出　　处：《Chinese Journal of Chemistry》2023年第22期3031-3036,I0002,共7页中国化学（英文版）

基　　金：the Independent Research Foundation of Key Laboratory of Green and Precise Synthetic Chemistry and Applications in Huaibei Normal University,Ministry of Education;the University Top Talents Academic Funding Project of Anhui Province(gxbjzD2021097);the Natural Science Foundation of Educational Committee from Anhui Province and Huaibei Normal University(KJ2020A0045,KJ2020A1199,KJ2020B01,2023ZK078,2023ZK079);the University Synergy Innovation Program of Anhui Province(GXXT-2020-078)for financial support of this work.

摘　　要：Herein,a DMAP-catalyzed[4+2]annulation ofα-substituted allenoates with arylazosulfones is reported,which affords facile access to tetrahydropyridazine derivative in synthetically useful yields.This reaction features mild conditions and good functional group tolerance.Moreover,the resultant products can be readily transformed into pyridazin-3-one derivatives in the presence of DDQ.

关 键 词：DMAP [4+2]Cycloaddition Tetrahydropyridazihe derivatives Pyridazin-3-one derivatives ALLENES ZWITTERIONS N-HETEROCYCLES 

分 类 号：O62[理学—有机化学]