神经反馈增强积极情绪在抑郁症治疗中的应用  

The application of neurofeedback for positive emotion enhancement in depression treatment

作　　者：车强燕 孙韵琳 靳佳 朱春燕[1,2,3,4] 汪凯 叶榕[1,2,4] 余凤琼 CHE Qiangyan;SUN Yunin;JIN Jia;ZHU Chunyan;WANG Kai;YE Rong;YU Fengqiong(Department of Mental Health and Psychological Science,Anhui Medical University;Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health;Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders;Anhui Institute of Translational Medicine;Department of Neurology,the First Affiliated Hospital of Anhui Medical University,Hefei 230032,China)

机构地区：[1]安徽医科大学精神卫生与心理科学学院 [2]脑疾病与心理健康安徽省协同创新中心 [3]认知与神经精神疾病安徽重点实验室 [4]安徽省转化医学研究院 [5]安徽医科大学第一附属医院神经内科,合肥230032

出　　处：《心理科学进展》2024年第2期342-363,共22页Advances in Psychological Science

基　　金：国家自然科学基金面上项目(32371134,31771222);安徽省高校自然科学研究重点项目(2022AH050678);安徽省转化医学研究项目(2021zhyx-C29);安徽医科大学基础与临床合作研究项目(2022sfy001);安徽省高校省级质量工程项目(2022jyx);科技惠民专项(2022e07020077)资助。

摘　　要：积极情绪的增强对抑郁症患者的临床症状改善和社会功能恢复具有重要意义。近年来神经反馈技术的发展为调控抑郁症积极情绪提供了有效的手段。传统积极情绪干预方法主观性强、治疗效果局限、缺乏可量化的客观评价指标,基于客观生理和影像指标的神经反馈技术在增强抑郁症积极情绪中具有重要的应用价值。神经反馈通过可视化方式将实时的大脑活动反馈给被试,让其能够使用特定的策略针对性地调控情绪相关脑区,客观定量地评价积极情绪的改善。现有的研究在实验范式、参数设置和个体疗效上存在较大异质性。通过回顾和总结神经反馈增强积极情绪的实验设计、研究的影响因素和基于神经影像标记物的目标靶点,强调了神经反馈实验设计和结果报告标准的重要性,探索性地提出了基于奖赏环路的潜在干预靶点及优化方案。有望为临床抑郁症积极情绪恢复提供可操作性的参考方案,为未来神经反馈技术在抑郁症临床症状治愈和社会功能康复中的转化应用和普及奠定基础。Positive emotion plays an important role in the improvement of clinical symptoms and the recovery of social function in patients with depression.In recent years,the development of neurofeedback technology provides an effective approach to enhance the positive emotion of depression.The traditional treatments that target the positive affect are subjective,have a relatively limited impact and lack of objective outcome measures.In contrast,neurofeedback technology based on objective physiological and image indicators has important clinical application value in enhancing positive emotions in depression.Neurofeedback,as a non-invasive technology,uses various electrophysiological methods and neuroimaging technologies to obtain real-time measurements of brain activity and provide feedback signals to subjects,so that the subjects can learn self-control over the activity in a brain area related to emotions through certain strategies.Crucially,it can evaluate objectively and quantitatively the improvement of positive emotions as well as provide more targeted treatments.However,the existing studies have great heterogeneity in experimental paradigms,parameter settings and individual efficacy.In this review,training protocols,the influencing factors of the protocols of neurofeedback and target brain regions of neurofeedback training based on imaging biomarkers will be discussed and summarized,the importance of standardization of experimental design and result reporting will be emphasized,and the potential treatment targets based on reward circuits and optimization schemes of neurofeedback will be recommended.It is expected to provide an operable reference scheme for positive emotion recovery in clinical depression.It lays a foundation for the clinical translation and popularization of neurofeedback technology in the treatment of clinical symptoms and social function rehabilitation of depression in the future.

关 键 词：积极情绪 神经反馈 抑郁症 快感缺失 脑电图 功能磁共振成像 

分 类 号：B845[哲学宗教—心理学]